J. Biomedical Science and Engineering, 2015, 8, 237-245 Published Online April 2015 in SciRes. http://www.scirp.org/journal/jbise http://dx.doi.org/10.4236/jbise.2015.84023 How to cite this paper: Ciocoiu, M., Badescu, M., Badulescu, O., Mocanu, M. and Badescu, C. (2015) Possibilities of Expe- rimental Modulation of Senescence by Stimulation of Antiradical Defense. J. Biomedical Science and Engineering, 8, 237- 245. http://dx.doi.org/10.4236/jbise.2015.84023 Possibilities of Experimental Modulation of Senescence by Stimulation of Antiradical Defense Manuela Ciocoiu 1 , Magda Badescu 1* , Oana Badulescu 1 , Madalina Mocanu 1 , Codruta Badescu 2 1 Department of Pathophysiology, Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, Iasi, Romania 2 Internal Medicine Clinic, St. Spiridon Hospital, University of Medicine and Pharmacy “Grigore T. Popa”, Iasi, Romania Email: * magda.badescu@gmail.com Received 10 March 2015; accepted 4 April 2015; published 8 April 2015 Copyright © 2015 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/ Abstract Various epidemiological studies have shown an inverse association between the consumption of polyphenols or polyphenol-rich foods and the risk of neurodegenerative, hepatic diseases. The research aimed to fight oxidative stress and lipid metabolism changes in the context of adminis- tration of antioxidants, such as polyphenolic extract of Aronia melanocarpa and zinc aspartate, known for its neurotrophic effects in intrinsic aging processes. Zinc aspartate and polyphenolic extract from Aronia melanocarpa reduce oxidative stress values both in serum, liver homogenate, and in brain homogenate. Oxidative stress assessed by malondialdehyde (MDA), glutathione pe- roxidase (GPx) and total antioxidant capacity (TAC) markers was reduced in animals receiving additional zinc salts and polyphenolic extract of Aronia melanocarpa, which underlines their role in antioxidant defense. This combination produces more superior hypolipidemic and antioxidant effects than in the case of separate administration within experimental senescence induced in the murine model. Further studies will investigate the effect of different dose combinations of zinc aspartate and polyphenolic extract of Aronia melanocarpa at different periods of treatments on age-associated liver/cerebral dysfunction. Keywords Senescence, Zinc Aspartate, Aronia melanocarpa, Oxidative Stress * Corresponding author.