The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells Ryutaro Aoki 1, 2, 5 , Tetsuhiro Chiba 1, 2, 3, 5 , Satoru Miyagi 1 , Masamitsu Negishi 1 , Takaaki Konuma 1 , Hideki Taniguchi 4 , Makoto Ogawa 2 , Osamu Yokosuka 2 , Atsushi Iwama 1, 3 * 1 Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan 2 Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan 3 JST, CREST, Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan 4 Department of Regenerative Medicine, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Kanagawa 236-0004, Japan 5 These authors contributed equally to this work. *Corresponding author: Atsushi Iwama, MD, PhD Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan Telephone: +81-43-2262187 Fax: +81-43-2262191 E-mail: aiwama@faculty.chiba-u.jp Number of figures and tables: 6 figures, 2 supplementary tables and 3 supplementary figures © 2010. This manuscript version is made available under the Elsevier user license http://www.elsevier.com/open-access/userlicense/1.0/