1 Supporting information Discovery of arginine ethyl ester as polyglutamine aggregation inhibitor: Conformational transitioning of huntingtin N-terminus augments aggregation suppression Virender Singh †& , Kinjal A. Patel ‡ , Raj Kumar Sharma § , Pratik R. Patil † , Abhayraj S. Joshi † , Rashmi Parihar † , Thamarailingam Athilingam † , Neeraj Sinha § , Subramaniam Ganesh † , Pradip Sinha † , Ipsita Roy ‡ , Ashwani Kumar Thakur* † † Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Uttar Pradesh 208016, India & Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, USA ‡ Department of Biotechnology, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Punjab 160062, India § Centre of Biomedical Research, SGPGIMS Campus, Raibarelly Road, Lucknow 226014, India *akthakur@iitk.ac.in