Receptor-selective mutants of Apo2L/TRAIL reveal a greater contribution of DR5 than DR4 to apoptosis signaling Robert F. Kelley,* 1 Klara Totpal, 2 Stephanie H. Lindstrom, 1 Mary Mathieu, 1 Karen Billeci, 4 Laura DeForge, 4 Roger Pai, 3 Sarah G. Hymowitz, 1 and Avi Ashkenazi 2 Depts. of Protein Engineering 1 , Molecular Oncology 2 , Process Sciences 3 , and Assay and Automation Technology 4 Genentech, Inc. 1 DNA Way South San Francisco, CA 94080 *Corresponding author: Robert F. Kelley, Ph.D. Dept. of Protein Engineering MS#27 Genentech, Inc. 1 DNA Way South San Francisco, CA 94080 (650)225-2321, fax#(650)224-3734, e-mail: rk@gene.com Running Title: Apoptosis-induction by DR5-selective Apo2L/TRAIL JBC Papers in Press. Published on November 1, 2004 as Manuscript M410660200 Copyright 2004 by The American Society for Biochemistry and Molecular Biology, Inc. by guest, on February 6, 2013 www.jbc.org Downloaded from