1 Title Pharmacokinetics and antitumor efficacy of paclitaxelͲcyclodextrin complexes loaded in mucusͲpenetrating nanoparticles for oral administration Author(s) names & affiliations Patricia Calleja a , Socorro Espuelas a , Leticia Corrales b , Ruben Pio b,c , Juan M. Irache a a Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain b Division of Oncology, Center for Applied Medical Research (CIMA), Pamplona, Spain c Department of Biochemistry, School of Sciences, University of Navarra, Pamplona, Spain Correspondence: Prof. Juan M. Irache Dep. Pharmacy and Pharmaceutical Technology University of Navarra C/ Irunlarrea, 1 31080 – Pamplona Spain Phone: +34948425600 Fax : +34948425619 EͲmail: jmirache@unav.es