TET1 drives global DNA demethylation via DPPA3-mediated inhibition of maintenance methylation Christopher B. Mulholland 1 , Joel Ryan 1† , Weihua Qin 1† , Michael D. Bartoschek 1† , Franziska R. Traube 2 , Edris Parsa 2 , Miha Modic 4 , Daniel Nixdorf 1 , Christoph Ziegenhain 3 , Thomas Carell 2 , Wolfgang Enard 3 , Sebastian Bultmann* 1§ and Heinrich Leonhardt* 1§ 1 Department of Biology II and Center for Integrated Protein Science Munich (CIPSM), Human Biology and BioImaging, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany 2 Center for Integrated Protein Science (CIPSM) at the Department of Chemistry, Ludwig-Maximilians-Universität München, Munich, Germany 3 Department of Biology II, Anthropology and Human Genomics, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany 4 The Francis Crick Institute and University College London, Institute of Neurology, London, United Kingdom † These authors contributed equally §These authors jointly supervised this work *Correspondence and requests for material should be addressed to S.B. (bultmann@bio.lmu.de) or H.L. (h.leonhardt@lmu.de) 1 not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprint (which was this version posted May 15, 2018. . https://doi.org/10.1101/321604 doi: bioRxiv preprint