Poster session S43 techniques. This enables all types of specialists to obtain a fast information exchange. Materials containing brief and extended theses of the reports are published before the conference begins. In the course of the conference sessions of the Problem Committee are held. In 2008 the conferences started holding review competitions of the papers of young scientists, post-graduates and students of the university departments training specialists in bio-medical technologies. In order to rapidly promote the new projects developed by these departments, an association of the departments, a special designing bureau, and an experimental plant are to be set up. A major role in forming the laser medicine information space is played by the International Science and Research Journal “Photobiology and photomedicine”. The Journal is on the list of Ukraine’s periodicals publishing papers of candidates for scientific degrees in biology and medicine. Work is now under way to include the Journal in the list of the periodicals for works of candidates for scientific degrees in technical sciences. The main sections of the Journal are entitled: “Clinical Pho- tomedicine”, “Photobiology and Experimental Photomedicine”, “Physical and Technical Foundations of Photobiology and Pho- tomedicine”. The Journal is published on the quarterly basis. The information support provided by the Problem Committee has made it possible to retain the Ukrainian school of laser medicine as well as maintain the high dynamics of its development. 129 NEW DEVICES AND METHODS FOR FLUORESCENT DIAGNOSTICS AND PHOTODYNAMIC THERAPY V.B. Loschenov, K.G. Linkov, A.A. Stratonnikov, N.N. Brysin. Laser Biospectroscopy Lab., Natural Science Research Center, A.M. Prokhorov General Physics Institute RAS, Moscow, Russia Introduction: Methods of optical diagnostics and photodynamic therapy are actively used in medical and biological researches. However wide application of PDT in clinics is limited to capabilities of the existing equipment. Materials and Methods: This paper presents the equipment developed in Laser Biospectroscopy Lab of A.M. Prokhorov General Physics Institute recently. Among the new developed therapeutic devices is a family of medical lasers for the photodynamic therapy, intended for use with new photosensitizers. General principles of construction of medical laser systems are presented. Key parameters of the developed lasers are given. Therapeutic lasers work in a red and near infra-red wavelength range, depending on application and photosensitizer. Output optical power of lasers is from 1.5 up to 30 Watts CW. Bright LED sources are good enough for irradiation of skin, while they are much cheaper than laser sources. A family of such devices, LED fluorescent system for a skin treatment, is presented at this paper. Devices allow to carry out therapeutic procedures and also to make a fluorescent diagnostics using various photosensitizers. Separate development shown in the paper is dual channel video colposcope system for the diagnostic of a cancer of a woman’s reproductive system. New opportunities of application of laser electronic spectrum analyzer LESA are considered also. Results: Hundreds patients was treated with above mentioned and similar equipment. Most interesting cases of gastric cancer, early lung cancer, basal cell carcinoma, paget’s disease and PDTof acne shown in the paper. Conclusion: Methods and devices shown in this paper will result in greater expansion of optical diagnostics and photodynamic therapy in the world. Equipment is developed on industrial base and with participation of experts from JSC “Biospec”. 130 BIOCHEMICAL EFFECTS OF LIGHT IRRADIATION AND KININS A.M. Makela. ABER Institute, Helsinki, Finland The primary changes in cells induced by light are followed by biochemical reactions which continue in darkness. These reactions are associated with the changes of cellular homeostasis, specifically the cellular redox state. The change of tissue pH is one of the regulating factors for kinin production. Kinins are potent vasodilator peptides generated in blood and tissues. Naturally occurring kinins and their active metabolites exert various biologic actions. Kinins are among the most potent activators of the arachidonic acid cascade, and they promote the release of prostaglandins and prostacyclins. Kinins also stimulate the release of histamine and 5-hydroxytryptamine from mast cells. They modulate the motility and the function of leukocytes, macrophages, fibroblasts, and other cells. Kinins are also implicated in the pathogenesis of inflammation, tissue reactions to injury, and tissue repair. Kinins release a potent endogenous vasodilator from the endothelium that reduces the arterial smooth muscle tone, increasing the blood flow to organs and reducing the systemic blood pressure. Kinins increase capillary permeability, by diminishing the size of the endothelial cells; they stimulate the veins; and also modulate the functions of blood and tissue cells. Therefore, light regulation of kinin production can explain some of the photobiological effects of light irradiation. 131 CHANGES OF PRODUCTION OF SOME BIOLOGICALLY ACTIVE SUBSTANCES BY THE ENDOTHELIUM UNDER LIGHT IRRADIATION (BIOCHEMICAL ASPECTS) A.M. Makela. ABER Institute, Helsinki, Finland Some of the therapeutic effects of light can be considered to be due to the changes in function of the endothelium. Endothelial cells produce and/or release a variety of substances that modulate vascular tone as well as growth, coagulation, platelet function, and the release of circulating hormones. Some of these are nitric oxide (NO), NO synthase, endothelium-derived hyperpolarizing factor, and prostacyclin (prostaglandin I 2 [PGI 2 ]), prostaglandins, endothelin, and angiotensin II. The presentation discusses the biochemical construct of NO synthase (source of NO) and light of different wavelenghts which can be absorbed by the different components on NO synthase and modulate its function. Several isoforms of the enzyme occur in endothelial cells, as well as in platelets, macrophages, vascular smooth muscle cells, and the brain. Relaxation of smooth muscle cells by NO is associated with activation of soluble guanylate cyclase (GC) and an increase in intracellular cyclic 3 ′ 5 ′ -guanosine monophosphate (cGMP) in vascular smooth muscle. Increased levels of cGMP in platelets are associated with reduced adhesion and aggregation. Endothelium derived NO is formed from L-arginine by oxidation of its guanidino- nitrogen terminal, also regulated by light. NO synthase reacts to light somewhat in the same pattern as cytochrome P450. 132 LOW-LEVEL LASER IRRADIATION IN THE COMPLEX THERAPY OF PATIENTS WITH COMPLICATED FORMS OF CHOLELITHIASIS A.V. Maximenkov, O.D. Tadjieva, O.V. Saakjan. State Research and Clinical Center for Laser Medicine, Moscow, Russia A complex application of techniques with low-level laser ir- radiation for treating complicated forms of cholelithiasis has been developed in State Research and Clinical Center for Laser Medicine. Patients who were operated on for choledocholithiasis and cholan- gitis had endocholedochial laser irradiation (CLI) in postoperative period. He-Ne laser apparatus “Atoll” with wavelength 632.8 nm