Vol. 14 | No. 2 |897-904| April - June | 2021 ISSN: 0974-1496 | e-ISSN: 0976-0083 | CODEN: RJCABP http://www.rasayanjournal.com http://www.rasayanjournal.co.in Rasayan J. Chem., 14(2), 897-904(2021) http://dx.doi.org/10.31788/ RJC.2021.1426252 This work is licensed under a CC BY 4.0 license. Morinda citrifolia LEAF EXTRACT MEDIATED GREEN SYNTHESIS OF COPPER OXIDE NANOPARTICLES AND IT’S POTENTIAL AND ANTIBACTERIAL STUDIES K. Sofiya Dayana 1,2, , R. Jothi Mani 2,3 and S.C. Vella Durai 4 1 Department of Physics, Sarah Tucker College (Autonomous), Manonmaniam Sundaranar University (Affiliated), Tirunelveli-627 007, Tamil Nadu, India 2 Department of Physics, Sadakathullah Appa College, (Autonomous), Tirunelveli-627 011, Tamil Nadu, India 3 Department of Physics, Fatima College (Autonomous), Madurai-625 018, Tamil Nadu, India 4 Department of Physics, JP College of Arts and Science, Agarakattu, Tenkasi- 627 852, Tamil Nadu, India (Affiliated to Manonmaniam Sundaranar University, Tirunelveli)  Corresponding Author: k.sofiyadayana@gmail.com ABSTRACT Eco responsive strategies of green mediate synthesis of nanoparticles are the current analysis within the extremity of nanotechnology. Copper Oxide nanoparticles (CuO Nps) based on Morinda citrifolia leaf extract were synthesized by a biological method and characterized by XRD, SEM, UV-DRS, Zeta potential, and FTIR. The high nutritionary worth of Morinda citrifolia could induce therapeutic effects, together with antimicrobial and antioxidant properties. XRD exhibits an orthorhombic structure. The aspect of functional groups and the chemical affiliation are analyzed by FTIR spectra. The potential of CuO Nps for the synthesis of nano-drug studied employing Zeta potential. SEM images show and confirm the morphology of the prepared Nps. The UV-DRS was used to monitor the bandgap energy of CuO Nps. The prepared samples have inhibiting higher to Flavobacterium psychrophilum bacteria. Hence, the current approach could be a facile, cost-efficient, reproducible, eco-friendly, and green methodology. Our report adscititious the worth for the appliance of Nps in medical specialty and nanotechnology applications with the absence of adverse facet effects. Keywords: Antibacterial Activity, Morinda citrifolia Leaf, SEM, UV-DRS, Zeta Potential. RASĀYAN J. Chem., Vol. 14, No.2, 2021 INTRODUCTION The synthesis of metal oxide Nps by the green method is an emerging research area. As the metal particles take bulk characterizes of the Nps disappears to be alternatively to that of a quantum dots 1-3 . Nanotechnology has created new opportunities for advances in many medical and biological applications such as cancer treatment, tissue regeneration, biosensing, medical imaging, and diagnosis, etc due to their novel properties that differ from their bulk materials 4,5 . Nanotechnology researches are the priority field and the forefront of modern research in recent years in different sciences such as medicine, physics, chemistry, biology, etc. Nanomaterials with their distinctive physical and chemical properties supported by numerous applications by dynamic their size, distribution, and morphology. Multiple methodologies were developed during this field to synthesize biocompatible Nps to fulfill the precise desires, in the main within the applications associated with the medicinal field. Metal Nps have recently attracted important attraction because of their explicit morphologies which are account for various applications 6 . The distinctive properties of metal oxide Nps arise from particularly their high surface-to-volume quantitative relation, the applications of metal oxide Nps, are receiving prime interest from researchers for their applications. CuO Nps are synthesized employing numerous conventional approaches; for instance: co-precipitation, sol-gel method, high energy ball milling, electrochemical and electrophoretic depositions, chemical vapor deposition, chemical vapor, and microwave-assisted combustion methods Noticeably, physical and chemical approaches may require high energy and also produce toxic byproducts