1 A description of large-scale metabolomics studies – Increasing value by combining 1 metabolomics with genome-wide SNP genotyping and transcriptional profiling 2 3 Georg Homuth 1 , Alexander Teumer 1 , Uwe Völker 1 , and Matthias Nauck 2 , 4 5 1 University Medicine Greifswald, Interfaculty Institute for Genetics and Functional Genomics, 6 Department of Functional Genomics, Friedrich-Ludwig-Jahn-Str. 15A, D-17487 Greifswald, 7 Germany. 8 9 2 University Medicine Greifswald, Institute for Clinical Chemistry and Laboratory Medicine, 10 Ferdinand-Sauerbruch-Straße, D-17475 Greifswald, Ferdinand-Sauerbruch-Straße, D-17475 11 Greifswald, Germany. 12 13 Corresponding author: 14 Georg Homuth 15 University Medicine Greifswald 16 Interfaculty Institute for Genetics and Functional Genomics 17 Department of Functional Genomics 18 Friedrich-Ludwig-Jahn-Str. 15A 19 D-17487 Greifswald, Germany 20 phone: ++49 3834 86 5873 21 fax: ++49 3834 86 7958 71 22 e-mail: georg.homuth@uni-greifswald.de 23 24 Page 1 of 40 Accepted Preprint first posted on 10 July 2012 as Manuscript JOE-12-0144 Copyright © 2012 by the Society for Endocrinology.