Research Article Successful Outpatient Management of Children at a Secondary Care Hospital in Pakistan in a Dengue Fever Epidemic and Their Clinical Outcomes Ammara Farooq, 1 Brekhna Aurangzeb, 2 Taimur Khalil Sheikh, 3 Huma Bashir, 3 Maryam Ghuncha, 4 and Tehmina Mustafa 5,6 1 Department of Pediatrics, Federal General Hospital, Islamabad, Pakistan 2 Department of Pediatrics, Pakistan Institute of Medical Sciences, Islamabad, Pakistan 3 Department of Pediatrics, Al Nafees Medical College and Hospital, Islamabad, Pakistan 4 Department of Pediatrics, Fazaia Medical College, Islamabad, Pakistan 5 Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway 6 Department of oracic Medicine, Haukeland University Hospital, Bergen, Norway Correspondence should be addressed to Tehmina Mustafa; tehmina.mustafa@uib.no Received 22 April 2021; Revised 27 September 2021; Accepted 9 October 2021; Published 2 November 2021 Academic Editor: Ran Wang Copyright © 2021 Ammara Farooq et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. ere is limited published literature on the feasibility of WHO 2009 guidelines for the management of dengue fever (DF) in Pakistani children. is study aimed to assess the outcome of children with DF who received outpatient treatment according to these guidelines during a DF epidemic. Method. is was a prospective cohort study conducted at Federal General Hospital, a secondary care hospital, Islamabad, Pakistan, from 1st August to 31st October 2019. Using WHO DF 2009 guidelines, children ≤13 years, diagnosed as confirmed DF (NS1 Ag +), were classified into the outpatient (DF) or the inpatient group (DF with warning signs or severe dengue (SD)). e inpatient group was admitted to the Pakistan Institute of Medical Sciences, a tertiary care hospital, and discharged on recovery. ese children were followed for the primary outcome, i.e., recovery or hospitalization by day 14 of enrollment. Additionally, clinical and laboratory features (Hb, HCT, TLC, PLT, and ALT) of the patients in the outpatient who remained stable with those who progressed to inpatient care during follow-up were compared; also, time of recovery of blood counts was assessed. Results. Of 93 children with DF, 87 (93.5%) received outpatient care at enrollment. Of these, 6 (7.8%) deteriorated by day 7 and were admitted to inpatient care. SD was present in 6/93 (6.4%) patients at presentation and were admitted. All children showed signs of recovery until day 14. Male gender (p � 0.049), lower normal mean platelet (p � 0.02), and high mean hematocrit (p � 0.001) were associated with disease progression. Conclusion. e majority of children with confirmed DF who received outpatient treatment according to WHO 2009 guidelines were successfully managed. Addi- tionally, confirmed DF with warning signs or SD were admitted and recovered. Regular follow-ups according to the guidelines are pertinent. rombocytopenia and high HCT were associated with disease progression. 1. Introduction Dengue fever (DF) is a mosquito born viral infection. ere are estimated 100 to 400 million infections every year and half of the world population is at risk of DF [1]. Its incidence has increased eightfold in the recent decades [1]. e major burden of the disease (70%) is in Asia [1]. DF is a single disease with a wide spectrum of presentation ranging from asymptomatic sero-conversion to mild DF or severe DF, which may lead to shock, severe bleeding, and death [2, 3]. It is an acute, self-limiting disease in most instances but a significant number results in hospital admissions principally Hindawi Journal of Tropical Medicine Volume 2021, Article ID 3296448, 10 pages https://doi.org/10.1155/2021/3296448