International Journal of Research and Review DOI: https://doi.org/10.52403/ijrr.20211032 Vol.8; Issue: 10; October 2021 Website: www.ijrrjournal.com Case Report E-ISSN: 2349-9788; P-ISSN: 2454-2237 International Journal of Research and Review (ijrrjournal.com) 248 Vol.8; Issue: 10; October 2021 Cavernous Sinus Thrombosis as Complications of Cellulitis Orbital: Case Report Astari Arum Cendani Goller 1 , Kumara Tini 2 1,2 Department of Neurology, Faculty of Medicine, Udayana University / Sanglah General Hospital Denpasar Corresponding Author: Astari Arum Cendani Goller ABSTRACT Background: Cavernous sinus thrombosis is a complication of infection around the face or paranasal sinuses with high morbidity and mortality rates. Cavernous sinus thrombosis is generally caused by septic infection, such as orbital cellulitis. Case Illustrations: A 35-year-old male who came to the neurology polyclinic complained of swelling in the left eyelid, red, watery eyes, blurred vision, difficulty opening the left eye, and the movement of the left eyeball felt normal. The patient had a history of left orbital cellulitis. Laboratory investigations showed an increase in inflammatory markers. The CT scan with contrast showed a hyperdense lesion in the left orbit, suggesting orbital cellulitis. The patient was diagnosed with a cavernous sinus thrombosis due to orbital cellulitis. He was treated with an antibiotic, anticoagulant, and corticosteroid. Three months after treatment, the visual complaints improved, the headache decreased drastically, and we did not find any extraocular muscles weakness. Conclusions: The administration of antibiotics and anticoagulant therapy in patients with cavernous sinus thrombosis has been proven clinically. The use of corticosteroids has not been proven but is strongly suspected to reduce edema caused by compression of the cavernous sinus. Keywords: Cavernous sinus thrombosis, orbital cellulitis, infections BACKGROUND Cavernous sinus thrombosis is a rare, life-threatening condition, as the complication of head infection or after traumatic injury or surgery, especially in patients with thrombophilic disorders.[1] The cause of cavernous sinus thrombosis is usually septic but can also be aseptic. Most infections are caused by Staphylococcus aureus (60-70%); fungal infections are only found in immunocompromised individuals. [2,3] The early symptoms of cavernous sinus thrombosis are fever, headache, periorbital swelling, and ophthalmoplegia. Although it can be treated with antibiotics and anticoagulation, the risk of long-term sequelae, such as vision, diplopia, and stroke, remains significant. There are residual symptoms in 50% of patients, such as third or sixth nerve palsy.[1] Complications include sepsis, meningitis, subdural empyema, brain abscess, blindness, panhypopituitarism, intracranial hypertension, infectious arteritis, internal carotid artery mycotic aneurysm, and vasospasm, septic embolism, stroke due to carotid constriction, cortical vein thrombosis, or hemorrhage, and death.[1, 2] We report a patient with cavernous sinus thrombosis as a complication of orbital cellulitis. CASE ILLUSTRATION A 35-year-old male came to the neurology polyclinic with a history of headaches since 11 months earlier, throbbing, especially on the left side, and sometimes radiating to the left eye, with mild intensity. The pain improves with