S1 Supporting Information Creation of a novel class of potent and selective MutT Homolog 1 (MTH1) inhibitors using fragment-based screening and structure-based drug design Fredrik Rahm, #§ Jenny Viklund*, # Lionel Trésaugues, # Manuel Ellermann, † Anja Giese, † Ulrika Ericsson, # Rickard Forsblom, # Tobias Ginman, # Judith Günther, † Kenth Hallberg, #‡ Johan Lindström, # Lars Boukharta Persson, # Camilla Silvander, # Antoine Talagas, # Laura Díaz-Saez, ∥,$ Oleg Fedorov, ∥,$ Kilian V. M. Huber, ∥,$ Ioanna Panagakou, ∥,$ Paulina Siejka, ∥,$ Mátyás Gorjánácz, † Marcus Bauser, † and Martin Andersson # # Sprint Bioscience AB, Novum, 141 57 Huddinge, Sweden † Bayer AG, Muellerstrasse 178, 133 53 Berlin, Germany ∥ Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, OX3 7DQ $ Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, OX3 7FZ