Int J Cur Res Rev | Vol 12 • Issue 24 • December 2020 2 Corresponding Author: Andi Nilawati Usman, Department of Midwifery, Graduate School, Hasanuddin University, Indonesia. E-mail: andinilawati@pasca.unhas.ac.id; nilawatiandi@gmail.com ISSN: 2231-2196 (Print) ISSN: 0975-5241 (Online) Received: 26.05.2020 Revised: 15.07.2020 Accepted: 25.08.2020 Published: 14.12.2020 Research Article International Journal of Current Research and Review DOI: http://dx.doi.org/10.31782/IJCRR.2020.122418 INTRODUCTION Women delivery may experience problems when labour takes place including rupture of the birth canal or perineum. More than 85% of vaginal deliveries will experience perine- al trauma and nearly 69% require. 1 The impact of perineal rupture on the mother such as infection of the bladder or on the birth canal. Bleeding can also occur due to the opening of blood vessels that do not close completely. Also, an in- creased risk of postpartum urinary retention, dyspareunia, and death can occur if treatment is slow. 2-4 The World Health Organization (WHO) estimates that around three-quarters of the population of developing coun- tries depend on traditional medicines (medicinal plants), for their primary health care needs. 3 In Indonesia, the use of plants around the house has happened since a long time ago, but only a little has been proven scientifically, so it needs to be proven scientifically so that the utilization of these plants is increasingly apparent. The main part of turmeric is the rhizome which contains two secondary metabolites of phenolic curcuminoids and essential oils. The main curcumi- noids found in turmeric are curcumin, demetoxy curcumin, and bisdemetoxycurcumin. 4 Research on the initial phyto- chemical content of the ethanol extract of Curcuma longa Linn7 and other studies showing the presence of curcumin, essential oils, tannins, alkaloids, saponins, flavonoids, terpe- noids which have important pharmacological activities such as anti-mutagenic, anti-inflammatory, antibacterial, antipro- . ABSTRACT Objective: The purpose of this study was to identify differences in wound healing and wound healing time at each concentration of turmeric extract gel (Curcuma longa Linn) and base gel on days 3, 7 and 14, and identify the most effective turmeric extract gel for wound healing in cuts female rats (Rattus Novergicus). Method: This study was an experimental laboratory using a post-test only with a control group. This study used 16 female rats, 3 treatment groups, and 1 control group (each group consisted of 4 mice). Female rats were injured in the back section by slash- ing along 1.5 cm with a depth of 0.2 cm. The treatment group was given turmeric extract gel with a concentration of 5%, 10%, 15%, and the control group was only given a gel base. This research was conducted for 14 days of topical turmeric extract gel by giving 2 times a day. The normality test uses the Shapiro Wilk test, then the Kruskal Wallis test, and continued with the Post- Hoc Mann-Whitney. Results: The mean on the 3rd day of the EG group was 5% (0.95cm), the EG group was 10% (0.98 cm), the group was 15% (1.23 cm), and the control group (1.25 cm). On the 7th day EG 5% (0.58 cm), EG 10% (0.65 cm), EG 15% (0.73 cm) and the control group (1 cm). On day 14 showed wound healing in the treatment group, but the control group showed mean wound length on day 14 (0.15 cm). Test results on day 3 obtained p = 0.007, on day 7 obtained p= 0.010 and on day 14 obtained p-value = 0.017. P values on days 3, 7, and 14 showed significant differences with p<0.05. Conclusion: There are differences in wound healing and wound healing time at each concentration of turmeric extract gel. Tur- meric extract gel concentration is the most effective healing wound cuts in female rats, namely the treatment group given EG 5%. Key Words: Turmeric extract, Gel, Female rat, Wound Effectiveness of Turmeric (Curcuma longa Linn) Extract Gel (EG) on Wound Healing in Female Rats (Rattus Novergicus) Arfiani Busman 1 , Andi Nilawati Usman 1 , Risfah Yulianty 2 , Mardiana Ahmad 1 , Prihantono 3 , Latifah Rahman 2 , Andi Sumidarti 4 1 Department of Midwifery, Graduate School, Hasanuddin University, Indonesia; 2 Faculty of Pharmacy, Hasanuddin University, Indonesia; 3 Faculty of medicine, Hasanuddin University, Indonesia; 4 Hasan Uddin University, Indonesia IJCRR Section: Healthcare Sci. Journal Impact Factor: 6.1 (2018) ICV: 90.90 (2018) Copyright@IJCRR