molbank Short Note N -[4-(1-Methyl-1H -imidazol-2-yl)-2,4 ′ -bipyridin-2 ′ - yl]benzene-1,4-diamine Dhafer S. Zinad 1, *, Dunya L. AL-Duhaidahaw 2 , Ahmed Al-Amiery 3, * and Abdul Amir H. Kadhum 4 1 Applied Science Department, University of Technology, Baghdad 10001, Iraq 2 Pharmaceutical Chemistry Department, College of Pharmacy, University of Kufa, AL-Najaf 31001, Iraq; dunyal.mohammed@uokufa.edu.iq 3 Energy and Renewable Energies Technology Center, University of Technology, Baghdad 10001, Iraq 4 Department of Chemical & Process Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Bangi, Selangor 43600, Malaysia; amir8@ukm.edu.my * Correspondence: dhafer.utech.78@gmail.com (D.S.Z.); dr.ahmed1975@gmail.com (A.A.-A.); Tel.: +964-770-171-9279 (D.S.Z.); +96-477-0067-1115 (A.A.-A.) Received: 29 October 2018; Accepted: 12 November 2018; Published: 16 November 2018   Abstract: N-[4-(1-Methyl-1H-imidazol-2-yl)-2,4 ′ -bipyridin-2 ′ -yl]benzene-1,4-diamine was synthesized with a good yield by the reaction of 2 ′ -chloro-4-(1-methyl-1H-imidazol-2-yl)- 2,4 ′ -bipyridine with 4-phenylenediamine. The functionalization of the pyridine was accomplished by a nucleophilic aromatic substitution (SNAr) reaction that afforded the target compound. The synthesized compound was characterized by chemical analysis, which includes nuclear magnetic resonance (NMR) ( 1 H-NMR and 13 C-NMR), Thin Layer Chromatography-Mass Spectrometry (TLC-MS), high-performance liquid chromatography (HPLC), Gas Chromatography-Mass Spectrometry (GC-MS), and elemental analysis. Keywords: 4-phenylenediamine; fluorescent; butanol; bipyridine; imidazole 1. Introduction Imidazoles are an important and essential class of heterocyclic compounds and include many substances of both biological and chemical interest. In literature, research and applications of imidazole-based compounds have been rapidly developed and they involve a variety of broad potential applications as medicinal drugs, agrochemicals, human-made materials, artificial acceptors, supramolecular ligands, biomimetic catalysts, and so on [1–3]. Medicinal properties of imidazole-containing compounds comprise a broad spectrum of pharmacological activities, including anticancer, antimicrobial, antibacterial, antifungal, antioxidant, and anti-Parkinson activities [4–6]. Insertion of heterocyclic molecules, such as pyrazole and pyridine moieties in an imidazole, remains of great interest due to the broad applications of such heterocycles in the pharmaceutical and agrochemical industry [7]. In continuation of previous studies [8–19], a new imidazole–bipyridine derivative was synthesized for the first time, accomplished by a nucleophilic aromatic substitution (SNAr) reaction (Scheme 1). Molbank 2018, 2018, M1030; doi:10.3390/M1030 www.mdpi.com/journal/molbank