Hippocampal Volume Is Associated with Memory but not Nonmemory Cognitive Performance in Patients with Mild Cognitive Impairment Michael Grundman,* ,1 Clifford R. Jack, Jr., 2 Ronald C. Petersen, 3 Hyun T. Kim, 1 Curtis Taylor, 3 Marina Datvian, 2 Myron F. Weiner, 4 Charles DeCarli, 5 Steven T. DeKosky, 6 Christopher van Dyck, 7 Sultan Darvesh, 8 Kristine Yaffe, 9 Jeffrey Kaye, 10 Steven H. Ferris, 11 Ronald G. Thomas, 1 and Leon J. Thal, 1 for the Alzheimer’s Disease Cooperative Study † 1 Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0949; Departments of 2 Diagnostic Radiology and 3 Neurology, Mayo Clinic and Foundation, Rochester, MN 55905; 4 Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9070; 5 Department of Neurology, University of California, Davis, Lawrence J. Ellison Ambulatory Care Center, Sacramento, CA 95817; 6 Department of Neurology, University of Pittsburgh, UPMC Health System, Pittsburgh, PA 15213; 7 Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510; 8 Queen Elizabeth II Health Sciences Centre, Camp Hill Veteran’s Memorial, Halifax, NS, B3H 2E1; 9 Department of Psychiatry, Neurology and Epidemiology, University of California, San Francisco, San Francisco, CA, 94121; 10 Department of Neurology, Oregon Health and Science University, CR131, Portland, OR, 97201; 11 Department of Psychiatry, New York University School of Medicine; New York, NY 10016 Received October 15, 2002; Accepted March 24, 2003 Journal of Molecular Neuroscience Copyright © 2003 Humana Press Inc. All rights of any nature whatsoever reserved. ISSN0895-8696/03/20:241–248/$25.00 Journal of Molecular Neuroscience 241 Volume 20, 2003 *Author to whom all correspondence and reprint requests should be addressed. E-mail: mgrundman@ucsd.edu † Members of the Alzheimer’s Disease Cooperative Study who are participating in this MRI study include John Adair, University of New Mexico, Albuquerque; Geoffrey Ahern, University of Arizona, Tucson; Bradley Boeve, David Knopman, Mayo Clinic, Rochester; Sandra Black, Sunnybrook Health Sciences, Toronto; Jeffrey Cummings, University of California, Los Angeles; Sultan Darvesh, Queen Elizabeth II Health Sciences Centre, Halifax; Charles DeCarli, Grisel J. Lopez, Kansas University, Kansas City; Steven DeKosky, University of Pittsburgh; Ranjan Duara, Wien Center, Miami Beach; Charles Echols, Barrow Neurology Group, Phoenix; Howard Feldman, U.B.C. Clinic for Alzheimer’s Disease, Vancouver; Steven Ferris, Mony deLeon, New York University Medical Center; Serge Gauthier, McGill Centre for Studies in Aging, Verdun, PQ; Neill Graff-Radford, Mayo Clinic, Jacksonville, FL; Danilo Guzman, E. Bruyere Memory Disorder Research, Ottawa; Jeffrey Kaye, Oregon Health and Science University, Portland; Alan Lerner, University Hospitals Health System, Cleveland; Richard Mar- golin, Vanderbilt University, Nashville; Marsel Mesulam, Northwestern University, Chicago; Richard Mohs, Mt. Sinai School of Medicine, Bronx, NY; John Olichney, University of California, San Diego; Brian Ott, Memorial Hospital of Rhode Island, Pawtucket; Elaine Peskind, University of Washington, Seattle; Nunzio Pomara, Nathan Kline Institute for Psychiatric Research, Orangeburg; Christopher van Dyck, Yale University School of Medicine, New Haven; Myron Weiner, University of Texas Southwestern Medical Center, Dallas; and Kristine Yaffe, University of California, San Francisco. EARLY DETECTION