Assessment of Metabolites Exposure in Preclinical Species and Humans at Steady State from the Single Dose Radiolabelled ADME Studies: A Case Study Chandra Prakash , Zhaoyang Li, Cesare Orlandi and Lewis Klunk Department of Drug Metabolism and Preclinical Safety, Biogen Idec, Cambridge, MA (CP, ZL, LK) and Cardiokine, Inc, Philadelphia, PA (CO) DMD Fast Forward. Published on April 3, 2012 as doi:10.1124/dmd.112.044933 Copyright 2012 by the American Society for Pharmacology and Experimental Therapeutics. This article has not been copyedited and formatted. The final version may differ from this version. DMD Fast Forward. Published on April 3, 2012 as DOI: 10.1124/dmd.112.044933 at ASPET Journals on November 26, 2021 dmd.aspetjournals.org Downloaded from