International Journal of Research in Medical Sciences | February 2020 | Vol 8 | Issue 2 Page 396 International Journal of Research in Medical Sciences Singh A et al. Int J Res Med Sci. 2020 Feb;8(2):396-400 www.msjonline.org pISSN 2320-6071 | eISSN 2320-6012 Original Research Article Outcome analysis in patients with multi vessel coronary artery disease and left ventricular ejection fraction after percutaneous coronary intervention: single center experience Abhimanyu Singh, Tanmay Banerjee, Dilip Kumar* INTRODUCTION Cardiovascular disease is one of the leading causes of mortality in the world, accounting for 29.3% of all deaths. 1 The burden from cardiovascular diseases are rapidly increasing in developing countries due to rapid population growth, ageing and globalized lifestyle. 2 Multi-vessel lesions are considered as an independent predictor of coronary artery disease (CAD) which commonly leads to serious complications such as heart enlargement, heart failure, malignant arrhythmias and even sudden cardiac death, that impacts the quality of life and life expectancy of a patient. 3 Coronary artery bypass graft surgery (CABG) has remained as the gold standard for the management of multi-vessel CAD, despite of technological advances in equipment and devices for percutaneous coronary intervention (PCI). The guidelines by ACC/AHA and ESC/EACTS also indicate CABG as the first line management strategy for the patients with multi-vessel CAD and depressed left ventricular ejection fraction. 4-6 The patients with left ventricular (LV) dysfunction once ABSTRACT Background: The present study evaluated the changes in baseline left ventricular function and clinical symptoms in multi-vessel coronary artery disease patients after multi-vessel percutaneous coronary intervention. Methods: This was a prospective, observational study conducted at Medical Super-speciality Hospital, Kolkata, India, between August 2017 and August 2019. The study included 48 patients who were diagnosed with ≥2 coronary artery stenosis of ≥50% in native coronary arteri es with left ventricular ejection fraction (LVEF) <40%. Echocardiography was performed before and after 3 months of the procedure to observe LVEF. Canadian Cardiovascular Society (CCS) score was calculated before and after 3 months after PCI. Results: Mean age of the patients was 61.89±9.96 years and 89.6% patients were male. Mean LVEF before and after angioplasty was 34.9±4.95% and 42.06±8.78%, respectively (p=0.001). CCS score before and after angioplasty was 2.89 and 1.83, respectively (p=0.001). Conclusions: The results displayed significant improvement in clinical symptoms as well as LVEF after PCI in patients with multi-vessel disease with LVEF <40%. These results will be helpful to conduct larger randomized trials with long term follow-up in order to prove the safety and effectiveness of PCI in such patients over coronary artery bypass grafting. Keywords: Ejection fraction, Left ventricular dysfunction, Multi-vessel disease, Percutaneous coronary intervention Department of Cardiology, Medica Institute of Cardiac Sciences, Kolkata, West Bengal, India Received: 11 December 2019 Revised: 23 December 2019 Accepted: 27 December 2019 *Correspondence: Dr. Dilip Kumar, E-mail: dilip.kumar@medicasynergie.in Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20200215