_____________________________________________________________________________________________________ *Corresponding author: E-mail: diyor-qosimov91@mail.ru; Journal of Pharmaceutical Research International 33(47B): 556-563, 2021; Article no.JPRI.76454 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Possibility of Using Bacteria-Destructors for Cypermetrin Degradation Diyorbek Kosimov 1* , Lyudmila Zaynitdinova 1 , Roxila Jo’rayeva 1 , Svetlana Kukanova 1 , Rustam Ergashev 1 , Azimjon Mamadrakhimov 2 , Lukmonjon Mutalliev 2,3 and Farkhod Eshboev 4 1 Institute of Microbiology of the Academy of Sciences of the Republic of Uzbekistan, A. Kadyri Str. 7B, 100128, Tashkent, Uzbekistan. 2 Institute of Bioorganic Chemistry, UzAS, M. Ulugbek Str. 83, 100125, Tashkent, Uzbekistan. 3 Turin Polytechnic University in Tashkent, Tashkent, Uzbekistan. 4 Institute of Chemistry of Plant Substances of the Academy of Sciences of the Republic of Uzbekistan, Ulugbek St. 77, 100170, Tashkent, Uzbekistan. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2021/v33i47B33155 Editor(s): (1) Dr. Paola Angelini, University of Perugia, Italy. Reviewers: (1) Dodo Juliet Dingtsen, University of Jos, Nigeria. (2) Graciela Pucci, Universidad Nacional de la Patagonia San Juan Bosco, Argentina. Complete Peer review History: http://www.sdiarticle4.com/review-history/76454 Received 13 August 2021 Accepted 27 October 2021 Published 04 November 2021 ABSTRACT From soils artificially contaminated with cypermethrin, 3 isolates were obtained that were resistant to cypermethrin concentrations of 40 mg/kg soil, and their morphological, cultural and biochemical properties were studied. On the basis of the obtained strains, a bacterial consortium was developed, which consists of the cultures of Pseudomonas sp., Bacilus sp. and Ochrobactrum sp. Laboratory experiments on the decomposition of cypermethrin showed the effectiveness of this consortium, within 28 days the decomposition of cypermethrin (40 mg/kg) was 100%. Keywords: Biodegradation; bacterial consortium; pseudomonas; ochrobactrum; Bacillus; pesticides; cypermethrin. Original Research Article