Research Article Evaluation of Antioxidant Potentials and -Amylase Inhibition of Different Fractions of Labiatae Plants Extracts: As a Model of Antidiabetic Compounds Properties Soheila Moein, 1,2 Elham Pimoradloo, 3 Mahmoodreza Moein, 4,5 and Mahmood Vessal 6 1 Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran 2 Department of Biochemistry, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran 3 Department of Biochemistry, Fars Sciences and Research Branch, Islamic Azad University, Shiraz, Iran 4 Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran 5 Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran 6 Department of Biochemistry, Faculty of Basic Sciences, Islamic Azad University of Shiraz, Sadra City, Fars, Iran Correspondence should be addressed to Mahmoodreza Moein; mrezamoein@yahoo.com Received 19 May 2017; Accepted 27 July 2017; Published 10 September 2017 Academic Editor: Kazim Husain Copyright © 2017 Soheila Moein et al. Tis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In an attempt to identify herbal drugs which may become useful in the prevention of diabetes, antioxidant potentials and -amylase inhibition by the ethanol extracts of two plants belonging to Lamiaceae family, Otostegia persica and Zataria multifora, and their diferent fractions were studied. Also, inhibition of -amylase by Salvia mirzayanii and its fractions was evaluated. All of the samples exhibited antioxidant activities, among which ethyl acetate fraction of Zataria multifora (17.21 ± 0.17 mg GAE/g) was found to contain the highest amounts of phenols and the ethyl acetate fraction of Zataria multifora (218 ± 2.76 mg QUE/g) had the most values of favonoids. Ethyl acetate fraction of Zataria multifora (IC 50 = 3.05 ± 0.51 g/ml) was shown to have the most reducing power and the ethyl acetate fraction of Zataria multifora (IC 50 = 32.17±1.82 g/ml) exhibited the highest DPPH radical scavenging. Te ethyl acetate fraction of Otostegia persica (99.39 ± 0.94%) showed the highest -amylase inhibitory activity which was similar to acarbose used as a standard. Mode of -amylase inhibition of the most samples was uncompetitive except for ZMC, OPP, OPC, and SMP which presented competitive inhibition. Te present fndings showed that studied samples may have some compounds with antioxidant and antidiabetic efects. 1. Introduction Type 2 diabetes (T2D) afects a large population worldwide. T2D is a complex heterogeneous group of metabolic disor- ders including hyperglycemia and impaired insulin action and/or insulin secretion and causes dysfunctioning of multi- ple organs or tissues. Current theories of T2D include a defect in insulin-mediated glucose uptake in muscle, a dysfunction of the pancreatic -cells, a disruption of the secretory func- tion of adipocytes, and an impaired insulin action in the liver [1]. Te early stage of type 2 diabetes is associated with post- prandial hyperglycemia due to impaired pancreas afer meal. Hyperglycemia is believed to increase the production of free radicals and reactive oxygen species, leading to oxidative tissue damage and diabetic complications such as nephropa- thy, neuropathy, retinopathy, and memory impairment [2]. Glucosidases are a group of digestive enzymes which break down the dietary carbohydrates into simple monosac- charides. Glucosidase inhibitors such as acarbose reduce the rate of carbohydrate digestion and delay the carbohydrate absorption from the digestive tract; therefore, they have a potential to prevent the development of type 2 diabetes by lowering the afer meal glucose levels [3]. Natural compounds from ancient times have been regarded as the most important sources of supplying drugs and now half of the drugs are from natural origin. In recent years, because of the availability of these compounds, having renewable resources, low toxicity, and low cost for preparing them [4], there is a tendency Hindawi BioMed Research International Volume 2017, Article ID 7319504, 8 pages https://doi.org/10.1155/2017/7319504