ORIENTAL JOURNAL OF CHEMISTRY www.orientjchem.org An International Open Access, Peer Reviewed Research Journal ISSN: 0970-020 X CODEN: OJCHEG 2019, Vol. 35, No.(4): Pg. 1248-1253 This is an Open Access article licensed under a Creative Commons license: Attribution 4.0 International (CC- BY). Published by Oriental Scientific Publishing Company © 2018 Synthesis of Fluoroquinolones derivatives as Antimicrobial Agents LUBNA SWELLMEEN 1 *, AMAL UZRAIL 2 , RAND SHAHIN 3 and YUSUF AL-HIARI 4 1 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Zarqa University, Jordan. 2 Department of Medical Analysis, Faculty of Allied Medical Sciences, Zarqa University, Jordan. 3 Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Hashemite University, Jordan. 4 Faculty of Pharmacy, The University of Jordan, Amman 11942, Jordan Zarqa. *Corresponding author E-mail: lswellmeen@zu.edu.jo http://dx.doi.org/10.13005/ojc/350401 (Received: April 08, 2019; Accepted: August 05, 2019) ABSTRACT Fluoroquinolones are well known to have an anti-infective action. In the present study we have described the synthesis of novel florouquinolones derivative as antimicrobial agent. The biological test highlighted a good inhibitory activity for the 7-Chloro-1-Alkyl-6-fluoro-8-nitro-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid derived synthons especially against pathogenic Gram-negative bacteria (Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus and Streptococcus agalactiae). The binding interactions were monitored and could explain the good inhibitory activity of the synthesized derivatives of florouquinolones. Keywords: Florouquinolones derivatives, Antibacterial activity, Gram-negative bacteria and Gram-positive bacteria. INTRODUCTION Anti-infective agents played a major role in saving human lives. Among these agents are the fluoroquinolones class, which had risen to be highly appreciated, especially if there was microbial resistance against penicillin and macrolide. Fluoroquinolone pharmacophore (Fig. 1) is well known to have antibacterial activity, and since 1980 there were many generation introduced to the market 1 . The fluoroquinolones were found to be effective to combat urinary tract infection 1 ideal in treating Neisseria gonorrhea 1 and highly effective to treat tuberculosis 2 . In addition, fluoroquinolone nucleus are presented widely in biologically active compounds such as PDE 4 inhibitors 3 , PIM kinase inhibitors 4 , GSK β inhibitors 5 . Fig. 1. Fluoroquinolone general formula The encouraging properties of fluoroquinolones such as; broad spectrum of activity, good oral bioavailability, good tissue penetrability and low incidence of adverse effect 6 gave them high appreciation and encouraged researcher to