Molecular Dynamics DOI: 10.1002/anie.200502655 Biomolecular Modeling: Goals, Problems, Perspectives Wilfred F. van Gunsteren,* Dirk Bakowies, Riccardo Baron, Indira Chandrasekhar, Markus Christen, Xavier Daura, Peter Gee, Daan P. Geerke, Alice Glättli, Philippe H. Hünenberger, Mika A. Kastenholz, Chris Oostenbrink, Merijn Schenk, Daniel Trzesniak, Nico F.A. van der Vegt, and Haibo B. Yu Angewandte Chemie Keywords: computer simulation · force-field techniques · GROMOS · molecular modeling · molecular dynamics W. F. van Gunsteren et al. Reviews 4064 www.angewandte.org  2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Angew. Chem. Int. Ed. 2006, 45, 4064 – 4092