1264| International Journal of Pharmaceutical Research | Oct - Dec 2020 | Vol 12 | Issue 4 Research Article Formulation and evaluation lipid polymer hybrid nanocarriers using a new innovative microwaves based method HAYDER KADHIM DRAIS 1* , AHMED ABBAS HUSSEIN 2 1 Ministry of health and environment, Babylon health directorate, Babylon, Iraq. 2 Department of pharmaceutics, college of pharmacy, university of Baghdad, Baghdad, Iraq. *Corresponding Author Email ID: deera2020@gmail.com Received: 10.04.19, Revised: 16.05.20, Accepted: 03.06.20 ABSTRACT Numerous problems in drug manufacturing methods drive towards finding an alternative for continued growth in the pharmaceutical industry in a way that serves the patients and community health. Preparability was tested for the microwaves based method that depends on dipole rotation and ionic conduction. The experiment was very successful during the preparation attractive delivery system which is lipid polymer hybrid nanocarrier (LPHN). The prepared LPHNs (F1-F7) compose of hydroxypropylmethylcellulose( HPMC) E5 suspended in the lipid phase of garlic / oleic acid oils(1:1) and stabilized by Tween80/Tween 20 (4:1). The LPHNs(F1-F7) were subjected to thermodynamic stability evaluation, measurement of particle size, polydispersity index (PDI) and viscosity. The result was all formulations have nanosize diameter. The polydispersity index (PDI) was from (0.011 to 0.03). The zeta potential was (31.1 mV to 33.4 mV). The viscosity data of nanocarrier systems indicate non-Newtonian pseudoplastic rheological properties of prepared F1-F7. All the prepared nanoformulations have excellent features that make it promising drug delivery systems. From these nanocarriers (F1 –F7), the selected nanocarrier was F3 due to this nanocarrier contain more acceptable in drug loading efficiency and more controlled delivery. Keywords: Lipid-polymer hybrid nanocarrier; microwave; HPMC. INTRODUCTION In the recent period, nanotechnology is beginning to take a more advanced trend in all fields of life and the pharmacy field in particular [1]. The lipid- polymer hybrid nanocarriers (LPHNs) was appeared to be a witness to the high potential of nanoscience in the development of the pharmaceutical industry and to show the true level of discovered drugs. The LPHN is an association between lipid-based and polymeric nanoparticle drug delivery systems. It emerges to overcome many demerits of these systems such as degradation and employment of organic solvent during the preparation, less stable during storage, sterilization problem and drug leakage [2,3]. It has sustained drug release effect, tissue targeting, higher drug loading capacity, furiousness an in vitro and in vivo stability [4]. Many of the newly discovered drugs have a problem of limited solubility in water and this leads to a reduction in their effectiveness in the body because, without drug solubility in vital fluids, the medicament cannot cross body barriers and access to blood circulation. The LPHN drug delivery system can solve such problems and load drugs that have poor water solubility. In addition to the hydrophobic drugs, there are many effective hydrophilic drugs its activity greatly reduced in the absence suitable delivery system. The LPHNs can encapsulate both hydrophobic and hydrophilic drugs. The strategy of dual active pharmaceutical agent-encapsulation overcome to the multiple drug resistance thus enhance its activity [5]. The prepared LPHNs compose of hydroxypropylmethylcellulose( HPMC) E5 suspended in the lipid phase of garlic oil/ oleic acid (1:1) and stabilized by Tween80/Tween 20 (4:1). Mostly, the lipid and polymeric core associated through electrostatic interactions, Vander walls bonds, hydrophobic forces, and can be conjugated by covalent bonds to the surrounding lipids [6,7]. The HPMC is a hydrophilic polymer and has the ability to loading hydrophilic drugs. It was used in various oral controlled drug delivery. The high swellability is an important feature of HPMC that related drug release kinetic. when water or biological media reach to HPMC, the relaxation of polymer and volume expansion take place. Then the loaded drug moves out of the formulation system [8,9]. Various strategies to formulate lipid-based hybrid nanocarrier but contain many drawbacks mainly time-consuming and cost-effective. The novel microwave method was used due to lower cost