DMD#47597 1 TITLE PAGE Effect of Solvents on the Time Dependent Inhibition of CYP3A4 and the Biotransformation of AZD3839 in Human Liver Microsomes and Hepatocytes Jenny Aasa, Yin Hu, Göran Eklund, Anders Lindgren, Pawel Baranczewski, Jonas Malmquist, Dominika Turek, and Tjerk Bueters DMPK, CNSP iMed Science, AstraZeneca R&D, Innovative Medicines, SE-15185 Södertälje, Sweden (J.A., Y.H., G.E., A.L., P.B., T.B.); Medicinal Chemistry, CNSP iMed Science, AstraZeneca R&D, Innovative Medicines, SE-15185 Södertälje, Sweden (D.T.); and Global DMPK Screening and Profiling, AstraZeneca R&D, SE-15185 Södertälje, Sweden (J.M.) DMD Fast Forward. Published on October 16, 2012 as doi:10.1124/dmd.112.047597 Copyright 2012 by the American Society for Pharmacology and Experimental Therapeutics. This article has not been copyedited and formatted. The final version may differ from this version. DMD Fast Forward. Published on October 16, 2012 as DOI: 10.1124/dmd.112.047597 at ASPET Journals on November 26, 2021 dmd.aspetjournals.org Downloaded from