Australian Journal of Basic and Applied Sciences, 7(9): 327-330, 2013 ISSN 1991-8178 Corresponding Author: Milan S. Vadodaria, Shree M. & N. Virani Science College,Kalawad Road,Rajkot–360 005, India E-mail: msvadodaria@vsc.edu.in 327 Studies on 4-Thiazolidinones: Part-1: Preparation and Antimicrobial Activity of 2- Aryl-3-(p- cumenyl)-5-H/methyl-4-thiazolidinones. Milan S. Vadodaria, Kartik D. Ladva, Viral R. Shah and A.R. Parikh Shree M. & N. Virani Science College, Kalawad Road, Rajkot–360 005, India Abstract: Some new 4-thiazolidinones have been prepared by the condensation of Schiff’s bases from p- cumidine with thioglycolic and thiolactic acids. The structures of the compounds have been delineated by IR, NMR and MASS spectral study. The products have been screened for antimicrobial activity; most of the compounds proved active. Key words: p- Cumidine, thioglycolic acid, thiolactic acid, Schiff’s bases, 4-thiazolidinones, antimicrobial activity. INTRODUCTION Several substituted 4-thiazolinones have been found to have many physiological activities 1-10 . . In continuation of our work to incorporate theses molecules into the p-cumidine moiety to explore the unknown pharmacological, herbicidal and insecticidal activity of p-cumidinederivatives,the synthesis of 4-thiazolidinones of type (3) has been schematised in 2 steps by the condensation of Schiff’s bases (2) from p-cumidine and aryl aldehydes with thioglycolic and thiolactic acid. The structures of the products have been characterised by IR, NMR, and MASS spectral study. The products have been screened for antimicrobial activity. Most of the compounds exhibited more activity than the reference antibiotic drugs. Reaction Scheme: NH 2 + R CHO N R N S R O X (i) (2) (3) (i) SH-CHX-COOH, ZnCl 2 Anhy, 120’C R = Aryl X = H/CH 3