Quality Assessment and Dissolution Profile Comparison Studies on Naproxen Tablets Available in Karachi ISSN 2521-8514 RADS J. Pharm. Pharm. Sci. 32 Open Access Full Length Article Quality Assessment and Dissolution Profile Comparison Studies on Naproxen Tablets Available in Karachi Fatima Qamar*, Samina Alam, Safila Naveed, Huma Ali Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan ABSTRACT Keywords: Physicochemical parameters, naproxen, model independent, model dependent method. Author`s Contribution All the authors contributed significantly to the research that resulted in the submitted manuscript. Article info. Received: October 11, 2016 Accepted: December 12, 2016 Funding Source: Nil Conflict of Interest: Nil Cite this article: Qamar F, Alam S, Naveed S, Ali H. Quality Assessment and Dissolution Profile Comparison Studies on Naproxen Tablets Available in Karachi. RADS J. Pharm. Pharm. Sci. 2017;5(2):32-35. *Address of Correspondence Author: fatimamudassar2009@hotmail.com Background: Naproxen, an NSAID, works by dropping down the hormones that cause inflammation as well as pain in the body. Naproxen is prescribed for the treatment of pain and inflammation, indicated for the conditions such as arthritis, spondylitis, ankylosing and tendinitis. Objective: The aim of this study is to compare six different brands of Naproxen Sodium. Methodology: Quality control parameters: weight variation test, thickness testing, hardness test, friability, disintegration and dissolution test were carried. Result: Result revealed that all the six brands comply within limits for hardness, weight variation, thickness, friability, disintegration test. Disintegration time for all brands was within 15 minutes complying with the USP commendation. Conclusion: The present findings suggest that all the brands meet the specification for quality control analysis. All the brands were best fitted with weibull model at pH 7.4. INTRODUCTION Naproxen is the most widely used NSAIDS for pain and inflammation caused by trauma, infection, auto immune disorders, neoplasms, joint degeneration and other causes [1-3]. By reversibly and non-selectively inhibiting COX isozymes, they exert their effects. It is particularly potent in inhibiting. leucocyte migration – may be more valuable in acute gout [4]. The usual dose is 250 – 550 mg twice a day that is recommended dose use for mild pain and inflammation and w/h higher dose used to treat most arthritic disorder [5]. It is orally administered & widely distributed drug and extensively metabolized by liver, having 1/2 of 14 hours. Adverse effects like gastric irritations, nausea, dyspepsia and bleeding is likely to be observed [6-8]. METHODOLOGY We have compared different parameters between the six different brands NEOPROX (propionic acid) tablet in order to ensure that a manufactured product adheres to a defined set of quality criteria. Test accomplished in order to conduct a comparative study between dualistic diverse brands of active naproxen, available in local market of Karachi, Pakistan, tested for subsequent physiochemical parameters to provide cost-effective alternative to patients. Following test parameters are accomplished to appraise the physicochemical parameters of accessible brands of naproxen. ORIGINAL ARTICLE