Correlation between Sonographic Findings of Maternal Thyroid Gland and Thyroid Function Tests during Pregnancy ISSN (Print): 2521-8514 ISSN (Online): 2521-8484 RADS J. Pharm. Pharm. Sci. 147 ORIGINAL ARTICLE Correlation between Sonographic Findings of Maternal Thyroid Gland and Thyroid Function Tests during Pregnancy Maimoona Rasool 1 , Sarah Maryam 1 , M. Sohail Anjum Noor 2 , Mehreen Fatima 1 , Sultan Ayaz 3, * Muhammad Numair Younis 4 , Syed Amir Gilani, Raham Bacha 1 , Maria Rasool 5 , Sadaf Ayesha 1 , Muhammad Yousaf Farooq 1 1 University Institute of Radiological Sciences & Medical Imaging Technology, Faculty of Allied health Sciences, The University of Lahore, Lahore Pakistan. 2 Independent Medical College, Faisalabad, Pakistan. 3 Department, Nuclear Medicine, Doctors Hospital & Medical Centre, Lahore, Pakistan. 4 Directorate of Medical Sciences, Government College University Faisalabad, Pakistan. 5 Government College University Faisalabad, Pakistan. ABSTRACT Authors’ Contributions 1-11 Conception & Study Design. 1 Data Collection and processing. 4 Data Analysis. 5 Drafting, Critical Review. Acknowledgement Article info. Received: November 11, 2020 Accepted: December 18, 2020 Funding Source: Nil Conflict of Interest: Nil Cite this article: Rasool M, Maryam S, Noor M.SA, Fatima M, Ayaz S, Younis MN, Gilani SA, Bacha R, Rasool M, Ayesha S, Farooq MY. Correlation between Sonographic Findings of Maternal Thyroid Gland and Thyroid Function Tests during Pregnancy. RADS J Pharm Pharm Sci. 2020; 8(3):147- 153. *Address of Correspondence Author: ayaz_libra@hotmail.com Background: Pregnancy has great influence on maternal thyroid gland. It induces significant physiological as well as hormonal changes that alters the maternal thyroid function. Our goal was to determine this pregnancy associated changes in thyroid gland. Objective: To correlate the sonographic findings of maternal thyroid gland with thyroid function tests during pregnancy. Material and methods: 135 pregnant women were recruited in this study, data of TSH, T3 and T4 was obtained and correlated it with the sonographic findings of maternal thyroid gland in each trimester of pregnancy. Results: In the 135 sampled pregnant women, mean thyroid gland volume was 4.08±1.19 cm 3 . The mean levels of T3, T4 and TSH were v3.37±.44 pmol/L, 14.96±2.49 pmol/L and 1.21±.92 mIU/L respectively. A remarkable correlation between thyroid hormones and thyroid volume was observed. Conclusion: It is concluded that the ultra-sonographic findings is correlated with the thyroid function tests during pregnancy. Keywords: Pregnancy, Tri-iodothyronine, Tetra-iodothyronine, Thyroid stimulating hormone, TSH, Ultrasonography, Correlation. INTRODUCTION Pregnancy has great influence on maternal thyroid gland. It induces significant physiological as well as hormonal changes that alters the maternal thyroid function. Thyroid gland size is affected by age, gender, iodine supply and TSH [1]. Thyroid gland volume is considered as a function of iodine intake in a population [2]. During gestation, the thyroid gland size increases about 10% in iodine sufficient countries and 20 to 40% in iodine deficient countries [3]. During a normal pregnancy, the physiology of thyroid gland is modified perceptibly. These changes occur throughout gestation and it helps the maternal thyroid gland to prepare and cope with the increased