International Journal of Research in Medical Sciences | March 2020 | Vol 8 | Issue 3 Page 1172 International Journal of Research in Medical Sciences Anant M et al. Int J Res Med Sci. 2020 Mar;8(3):1172-1179 www.msjonline.org pISSN 2320-6071 | eISSN 2320-6012 Case Report Borderline ovarian tumour of mixed seromucinous histology and bilateral presentation: a case report and review of literature Monika Anant 1 *, Sutapan Samanta 2 , Ruchi Sinha 3 INTRODUCTION Borderline ovarian tumors comprise about 15-20% of all epithelial ovarian malignancies with an incidence of 1.8- 4.8 per 100,000 women per year. 1-3 Borderline ovarian tumours (BOTs) demonstrate higher proliferative activity than the benign neoplasms, but do not invade the stroma like malignant ones, therefore are a distinct pathological subgroup of neoplasms. 4 Also known as tumours of low malignant potential (LMP), they were first described by Taylor. 5 Primary epithelial ovarian tumours were classified and subdivided into three groups: (a) benign cystadenoma; (b) cyst adenoma with proliferating activity of the epithelial cells and nuclear abnormalities, but with non-infiltrative destructive growth; and (c) cystadenocarcinoma by International Federation of Gynaecology and Obstetrics (FIGO) Cancer Committee (1961). 6 World Health Organization (WHO) applied the designation ‘tumour of borderline malignancy’ and added the synonym ‘carcinoma of low malignant potential’ (LMP) in their 1973 classification of ovarian tumours. 7 The presence single focus or multiple foci of micro invasion has also been recognised recently which may be with a specific histologic characteristics and of intermediate atypia, hence borderline ovarian tumours (BOT) are also referred to as atypical proliferative ovarian tumours (APOTs). 8 1 Department of Obstetrics and Gynaecology, AIIMS, Patna, Bihar, India 2 IVF consultant, Department of reproductive biology, Indira IVF-Kolkata, Kolkata, West Bengal, India 3 Department of Pathology and Lab Medicine, AIIMS, Patna, Bihar, India Received: 01 January 2020 Revised: 23 January 2020 Accepted: 29 January 2020 *Correspondence: Dr. Monika Anant, E-mail: drmonika.anant@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT This article reports the case of a 40 year old woman who presented to the gynaecologic outpatient clinic with pain lower abdomen and an abdominopelvic lump. Clinical assessment, biochemical and radiological investigations revealed bilateral complex ovarian masses. Surgical exploration and histology of ovarian masses confirmed a rare bilateral borderline seromucinous cystadenoma. The purpose of this paper is to highlight the importance of thorough examination of women with symptoms of ovarian tumour which can be vague and to emphasize the necessity of a good collaboration between various medical specialties (primary physician/gynaecologist, oncosurgeon, radiologist and histopathologist) for correct diagnosis, optimum care and best outcome. This article also provides overview of the pathology and biology of borderline ovarian tumours, diagnosis, principles of surgical management and to appreciate the value of follow up. Keywords: Borderline ovarian tumor, Bilateral, Seromucinous, Surgical staging DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20200801