INTRODUCTION Polycystic ovary syndrome (PCOS) is a common heterogeneous disorder of reproductive aged women with an estimated prevalence of 4-12%. 1 Inappropriate gonadotropin secretion including elevated LH/FSH ratio is a typical finding among women with PCOS and also thought to play an important role in ovulatory dysfunction. 2 However, when basal LH measurements were used as a diagnostic marker of PCOS, a significant number of patients failed to exhibit an elevated LH and hence, LH/FSH ratio. 3,4 Both recent ovulation and progesterone exposure transiently reduce the LH/FSH ratio in women with PCOS. 5,6 Furthermore, several studies have also shown that in PCOS women there is a negative influence of obesity on LH values. 7,8 Obese PCOS women have been observed to have decreased serum LH level as compared to lean PCOS patients. This study was, therefore, designed to evaluate the influence of adiposity in terms of anthropometric measurements on abnormal gonadotropin secretions (serum LH level and LH:FSH ratio) in women with PCOS. METHODOLOGY The study was carried out at IBMS, DUHS in collaboration with Gynae/infertility Clinics of two tertiary care hospitals (Civil Hospital and Lady Dufferin Hospital) in Karachi. The research proposal was approved from Ethical Review Board of Dow University of Health Sciences and all subjects were enrolled voluntarily in the study after being explained by concerned doctor and signing the consent form. One hundred and sixty three oligomenorrhic PCOS women (average duration of menstrual cycle 45 days) of childbearing age (18 - 40 years) fulfilling revised Rotterdam 2003 criteria were studied during the period from October 2010 to February 2011. PCOS women who were pregnant, or on any contraceptive pills or using oral hypoglycemic agents were excluded from the study. Amenorrhea PCOS women were also excluded from the study. A detailed history was taken on a pre-structured proforma that included current age, age at menarche, history of menstrual irregularity, acne, hirsutism, infertility, obstetric history and occurrence of similar cases in Journal of the College of Physicians and Surgeons Pakistan 2014, Vol. 24 (7): 463-466 463 ORIGINAL ARTICLE Influence of Anthropometric Measurements on Abnormal Gonadotropin Secretion in Women with Polycystic Ovary Syndrome Shehla Haider 1 , Nighat Mannan 1 , Ayesha Khan 2 and Masood A. Qureshi 1 ABSTRACT Objective: To evaluate the influence of anthropometric measurements on abnormal gonadotropin secretion in patients with polycystic ovary syndrome (PCOS). Study Design: Cross-sectional study. Place and Duration of Study: The Institute of Basic Medical Sciences (IBMS), DUHS in collaboration with Gynae/infertility clinics of the Civil Hospital and Lady Dufferin Hospital, Karachi, from October 2010 to February 2011. Methodology: One hundred and sixty three oligomenorrhic PCOS women of reproductive age (18 - 40 years) fulfilling the revised Rotterdam 2003 criteria were studied. The data recorded on a prescribed proforma included current age, age at menarche, menstrual irregularities, presence of hirsuitism, acne, infertility, familial nature, blood pressure, BMI and waist- hip ratio. Blood samples for gonadotropin assay were taken randomly on day 6th to 30th of menstrual cycle, in a gel tube. Hormonal assay was performed using chemiluminescent immunoassay. Kruskul Wallis test was used to assess the influence of BMI levels on LH:FSH values. Results: The mean weight was 66.14 ± 11.02 kg and mean BMI was 27.03 ± 4.42 kg/m 2 . There was no significant difference in mean LH/FSH ratio (p=.575) among BMI groups. However, there was a positive correlation between BMI and LH:FSH ratio (p=0.04, r=0.155). Conclusion: There was high frequency of obesity (69%) in women with PCOS. Although no significant difference was found between mean LH:FSH ratio among different BMI groups levels but significant correlation between BMI levels and LH: FSH suggested that there was positive relation between BMI and LH: FSH. Key Words: Polysystic overies syndrome (PCOS). Gonadotropin level. BMI. Waist- hip ratio (WHR). LH:FSH ratio. Department of Physiology 1 / Obstetrics and Gynaecology 2 , Dow University of Health Sciences (DUHS), Karachi. Correspondence: Dr. Shehla Haider, A-75/I, Shareefabad, F.B. Area, Karachi. E-mail: shehla.haider@yahoo.com Received: February 21, 2012; Accepted: March 19, 2014.