Journal of Dentistry Indonesia 2012, Vol. 19, No. 1, 14-19 14 ORIGINAL ARTICLE Radiotherapy Reduced Salivary Flow Rate and Might Induced C. albicans Infection Nadia Surjadi 1 , Rahmi Amtha 2 1 Undergraduate Program, Faculty of Dentistry Trisakti University, Jakarta 11440, Indonesia 2 Department of Oral Medicine, Faculty of Dentistry Trisakti University, Jakarta 11440, Indonesia Correspondence e-mail to:nadia.surjadi@gmail.com ABSTRACT Radiotherapy has impact in oral health especially on the secretion capacity of the salivary glands. Another impact is the increase of Candida albicans colony. Objectives: 7R HYDOXDWH VDOLYDU\ ﾀRZ UDWH LQ UHODWLRQ ZLWK &DQGLGD albicans colony in head and neck cancer patients during and after radiotherapy. Methods: 7ZHQW\IRXU KHDG DQG QHFN FDQFHU SDWLHQWV LQ 'KDUPDLV &DQFHU KRVSLWDO -DNDUWD ZKR ZHUH XQGHUJRLQJ UDGLRWKHUDS\ RU KDG XQGHUJRQH UDGLRWKHUDS\ DQG  PDWFK KHDOWK\ YROXQWHHUV ZHUH LQFOXGHG LQ WKH VWXG\ &OLQLFDO REVHUYDWLRQ FDUULHG RXW E\ FROOHFWLQJ XQVWLPXODWHG VDOLYDU\ ﾀRZ UDWH DQG IROORZHG E\ FXOWXUH RI &DQGLGD LQ 6DERUDXG DJDU PHGLXP 'DWD ZHUH DQDO\]HG VWDWLVWLFDOO\ E\ &KLVTXDUH Results: 1DVRSKDU\Q[ FDQFHU ZDV WKH PRVW IUHTXHQW W\SH RI KHDG DQG QHFN FDQFHUV  IROORZHG E\ WRQJXH FDQFHU  DQG IRXQG LQ  \HDUV ROG SDWLHQWV DQG  \HDUV ROG SDWLHQWV UHVSHFWLYHO\ ZLWK PDOH SUHGLOHFWLRQ FRPSDUH WR IHPDOH  $SSUR[LPDWHO\  RI VXEMHFWV VKRZHG GHFUHDVHG VDOLYDU\ ﾀRZ UDWH P/PLQ DQG  VKRZHG D QRUPDO VDOLYDU\ ﾀRZ UDWH P/PLQ GXULQJ DQG DIWHU UDGLRWKHUDS\ +RZHYHU  RI FDQFHU SDWLHQWV KDV LQFUHDVHG LQ C.albicans colony during and after radiotherapy compared to control (p Conclusion: 7KLV VWXG\ VKRZHG WKDW UDGLRWKHUDS\ LQGXFHG hyposalivation and might increase the C.albicans colony. ABSTRAK Radioterapi menurunkan laju aliran saliva dan meningkatkan infeksi C. albicans. Radioterapi memiliki GDPSDN OXDU ELDVD WHUKDGDS NHVHKDWDQ URQJJD PXOXW WHUXWDPD NHPDPSXDQ NHOHQMDU VDOLYD XQWXN PHPSURGXNVL VHNUHWQ\D 6DODK VDWX GDPSDNQ\D DGDODK SHQLQJNDWDQ MXPODK Candida albicans. Objektif 8QWXN PHQJHYDOXDVL ODMX DOLUDQ VDOLYD GDQ KXEXQJDQQ\D GHQJDQ NRORQL Candida albicans pada pasien kanker kepala leher selama dan pasca radioterapi. Metode: 6HEDQ\DN  RUDQJ SHQGHULWD NDQNHU NHSDOD OHKHU GL 56 .DQNHU 'KDUPDLV -DNDUWD \DQJ VHGDQJ GDQ SHUQDK PHQMDODQL UDGLRWHUDSL PDNVLPDO  WDKXQ SDVFD UDGLRWHUDSL VHUWD NRQWURO  RUDQJ VHKDW dimasukkan dalam populasi penelitian. Observasi klinik GLODNXNDQ XQWXN PHQJHYDOXDVL ODMX DOLUDQ VDOLYD WDQSD VWLPXODVL GLODQMXWNDQ GHQJDQ REVHUYDVL ODERUDWRULN GHQJDQ NXOWXU Candida dari sampel penelitian pada media agar 6DERUDXG 'DWD GLDQDOLVLV VWDWLVWLN GHQJDQ XML Chi-square. Hasil 3DGD SHQHOLWLDQ LQL GLGDSDW GXD MHQLV NDQNHU NHSDOD GDQ OHKHU \DLWX NDQNHU QDVRIDULQJ  GDQ NDQNHU OLGDK  GDODP UHQWDQJ XVLD  WDKXQ  GDQ  WDKXQ  VXEMHN GHQJDQ SHUEDQGLQJDQ SULD GDQ ZDQLWD  6HEDQ\DN  VXEMHN PHQXQMXNNDQ SHQXUXQDQ ODMX DOLUDQ VDOLYD P/PHQLW GDQ   VXEMHN NDQNHU PHQXQMXNNDQ ODMX DOLUDQ VDOLYD \DQJ QRUPDO P/PHQLW VHODPD GDQ VHWHODK UDGLRWHUDSL %HUEDQGLQJ WHUEDOLN GHQJDQ SHQLQJNDWDQ MXPODK C. albicans,  VXEMHN NDQNHU PHQJDODPL SHQLQJNDWDQ MXPODK C.albicans (p Simpulan: 3HQHOLWLDQ LQL PHQXQMXNNDQ EDKZD UDGLRWHUDSL PHPSHQJDUXKL WHUMDGLQ\D KLSRVDOLYDVL GDQ PHPSHQJDUXKL SHQLQJNDWDQ MXPODK koloni C. albicans. Key words: Candida albicans, ODMX DOLUDQ VDOLYD UDGLRWHUDSL