Revista Română de Medicină de Laborator Vol. 19, Nr. 2/4, Iunie 2011 Angiomatous hamartoma of the breast: a new entity developing in pediatric patients Hamartom mamar de tip angiomatos - entitate nou descrisă la copii Maria Daniela Podeanu 1* , Cristina Marian 2 , Constantin Copotoiu 3 , Klara Brânzaniuc 4 , Simona Stolnicu 2 1. Department of Radiology, University of Medicine and Pharmacy Tîrgu Mureş, România 2. Department of Pathology, University of Medicine and Pharmacy Tîrgu Mureş, România 3. Department of Surgery I, University of Medicine and Pharmacy Tîrgu Mureş, România 4. Department of Anatomy, University of Medicine and Pharmacy Tîrgu Mureş, România Abstract We report the case of a young prepuberal 11 year old patient who rapidly developed a breast hamar- toma with a prominent angiomatous (vascular) component that was observed on both radiological and patholo- gical examination, raising the possibility of other breast neoplasms. Only one case of vascular hamartoma of the breast in a 5 year old girl has been previously reported in the English literature. We discuss the main differential diagnostic problems and the possible histogenesis of this new entity. Keywords: breast hamartoma, angiomatous component, immunohistochemistry Rezumat Raportăm cazul unei paciente prepuberale de 11 ani, care a dezvoltat rapid la nivelul glandei mamare un hamartom ce prezintă o proeminentă componentă angiomatoasă (vasculară) identificată atât la examinarea radiologică cât şi la cea patologică. Leziunea ridică suspiciunea unor alte neoplasme mamare. Doar un singur alt caz de hamartom mamar la copii (o pacientă in vârstă de 5 ani) a mai fost descris până în prezent în literatu- ra de specialitate publicată în limba engleză. In cadrul articolului discutăm principalele probleme de diagnostic diferenţial şi histogeneza ale acestei noi entităţi. Cuvinte cheie: hamartom mamar, componentă angiomatoasă, imunohistochimie Introduction Hamartoma of the breast was initially defined as a malformation that resembles a neo- plasm but in 1971 Arrigoni described it for the first time as an encapsulated breast neoplasm that clin- ically and macroscopically resembled a fibro- adenoma but, in contrast with this, on microscopic * Corresponding author:Maria Daniela Podeanu, Department of Radiology, University of Medicine and Phar- macy Targu Mures, Str. Gheorghe Marinescu Nr. 38, Telefon: 0265215551 Fax: 0265210407, E-mail: danielapodeanu@yahoo.com 199