1-3 Krešimir Rotim 1-4 Bruno Splavski 1 Filip Vrban 1 Ante Rotim 1 Department of Neurosurgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia 2 J. J. Strossmayer University School of Medicine, Osijek, Croatia 3 University of Applied Health Sciences, Zagreb, Croatia 4 J. J. Strossmayer University School of Dental Medicine and Health, Osijek, Croatia Abstract Introduction: Brain glioma is the most common and lethal primary malignant intracranial tumor. Nonethe- less, gross tumor resection remains the most success- ful treatment modality, which may prolong progres- sion free survival of these patients. However, excessive surgery brings a danger of neurological, regional and systemic complications, which may be diminished/ avoided by better pre- and intra-operative care and by modern neurosurgical techniques. Aim: To analyze the incidence and type of peri- and post-operative complications in surgical brain glioma patients. Computing the results, advice on complica- tion prevention was made. Methods: A single institution series of brain glioma pa- tients operated on during a two-year period was ana- lyzed. The incidence, type and time of complications were observed, as well as the patients’ gender and age, and the extent of tumor resection complications, di- chotomized as peri- and post-operative variables, were correlated with investigated parameters to find out their possible association. Results: Transitory neurological deficit was the most common peri-operative complication. Seizures, men- ingitis, and permanent neurological deficit were com- monly recorded among post-operative complications. Conclusion: Patients’ gender and age, and the extent of tumor resection were not influential to the develop- ment of brain glioma complications. Aggressive surgery requires the avoidance of complications by cautious patient selection, multidisciplinary preoperative plan- ning, and scrupulous neurosurgical technique aug- mented by up-to-date armamentarium. Keywords: brain glioma,s treatment, complications, preven- tion strategies Article received: 05.12.2020. Article accepted: 15.01.2021. https://doi.org/10.24141/1/7/2/1 Corresponding author: Bruno Splavski A: Department of Neurosurgery, Sestre milosrdnice University Hospital Center, Vinogradska c. 29, 10 000 Zagreb, Croatia E-mail: splavuno@gmail.com T: +385 1 378 71 11 No sources of support in the form of grants or others were re- ceived. The authors report no potential conflicts of interest. Strategies for the Prevention of Complications in Brain Glioma Surgery: A Case Series Analysis J. appl. health sci. 2021; 7(2): 115-120