Secondary Endpoint of the Prosthodontics Publication History: Received: January 31, 2017 Accepted: April 23, 2017 Published: April 25, 2017 Keywords: Secondary endpoint, Chewing function, Occlusal rehabilitation, Oral diseases, Non-communicable diseases Review Article Open Access Introduction Te main goal of the dental medicine is the increment of health span and improvement of QOL through oral health. Prosthodontics is defned that the dental specialty that deals with the diagnosis, treatment planning, rehabilitation and maintenance of the oral function, comfort, appearance and health of these patients [1]. Traditional primary end point of the prosthodontics is restore and reshaping of oral functions. Te accumulated knowledge of prosthodontics makes it feasible that the precise evaluation of the oral functions based on the mandibular movement and occlusion and the more suitable dental materials for prosthodontic treatments have been developed. As a result, more sophisticated prosthesis can be created. However prosthodontists rely more on art and experience than science to diagnose oral problem and to decide on a treatment planning. Evaluation of oral function is fundamental for treatment success in prosthodontics and various objective methods for measuring oral function were reported in previous studies, nevertheless there have been a very few reports of the objective measurement and comprehensive assessment during complete feeding sequences from ingestion to fnal swallow in the clinical setting. Not surprisingly, objective evaluation results of oral functions in patient’s cannot be taken into account in the design of dental prostheses. Meanwhile, with the advances of the research for the oral health and systemic disorders, the oral health afected on the systemic disorders especially noncommunicable diseases. At earlier stage, it had been proposed that periodontal diseaseafect on the coronary heart disease[2-6], low birthweight [7-10] and obesity [11-13]. Recently, evidences that periodontal bacteria, especially Porphyromonas gingivalis,are the causative bacteria of the rheumatoid arthritis [14-16]or Alzheimer's disease [17-20] have been accumulated. Te mechanisms of these co-relations are perinatal bacteria and their pathogenic products invade into the blood vessels and ail distant organs. Tus, bacteremia is the essential context of the co-relation oral health and systemic diseases. *Corresponding Author: Dr. Yoshiaki Nomura, Department of Translational Research, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi- ku, Yokohama, Japan, Tel: +81-45-580-8462; E-mail: nomura-y@tsurumi-u.ac.jp Citation: Nomura Y, Takeuchi H, Shigemoto S, Okada A, Shigeta Y, et al. (2017) Secondary Endpoint of the Prosthodontics. Int J Clin Case Stud 3: 117. doi: https://doi.org/10.15344/2455-2356/2017/117 Copyright: © 2017 Nomura et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Meanwhile, with the advances of the research for the oral health and systemic disorders, the oral health afected on the systemic disorders especially noncommunicable diseases. At earlier stage, it had been proposed that periodontal disease afect on the coronary heart disease [2-6], low birth weight [7-10] and obesity [11-13]. Recently, evidences that periodontal bacteria, especially Porphyromonas gingivalis, are the causative bacteria of the rheumatoid arthritis [14-16]or Alzheimer's disease[17-20] have been accumulated. Te mechanisms of these co- relations are perinatal bacteria and their pathogenic products invade into the blood vessels and ail distant organs. Tus, bacteremia is the essential context of the co-relation oral health and systemic diseases. Recent main goal of the prosthodontic treatment is restore the masticatory function, however, in some cases, without taking into account a harmony among oral functions, longevity and esthetics, the decided treatment planning may not lead to an expected longevity of prosthodontic treatment, and without nutritional instruction, improved masticatory function may lead to foster malnutrition such as excess intake high-glycemic-index diet. To improve the mastication efciency is not objective, its only means. Final goal of the prosthodontics is improve the overall health by improving nutrition status, metabolic disorders, and body composition. Te secondary endpoint of prosthodontic treatment isto maintain improved chewing function based on the objective evaluation of oral function and to evaluate metabolism, body composition and prevention of odontogenic bacteremia. Terefore, dentist should aware that International Journal of Clinical Case Studies Yoshiaki Nomura 1,* , Hiroaki Takeuchi 1 , Shuji Shigemoto 2 , Ayako Okada 1 , Yuko Shigeta 2 ,Takumi Ogawa 2 and Nobuhiro Hanada 1 1 Department of Translational Research, Tsurumi University School of Dental Medicine, Yokohama, Japan 2 Department of Fixed Prosthodontics, School of Dental Medicine, Tsurumi University, Yokohama, Japan Int J Clin Case Stud IJCCS, an open access journal ISSN: 2455-2356 Volume 3. 2017. 117 Nomura et al., Int J Clin Case Stud 2017, 3: 117 https://doi.org/10.15344/2455-2356/2017/117 Abstract Traditional primary end point of the prosthodontics has been to restore and reshaping of oral functions. Te secondary endpoint of prosthodontic treatment is to maintain improved chewing function based on the objective evaluation of oral function and to evaluate metabolism, body composition and prevention of odontogenic bacteremia. Present article provides an overview of the candidate of secondary endpoint and recent advances of the primary endpoint of prosthodontic treatment. Our purpose of this article was to provide valuable information to achieve the secondary endpoint of the prosthodontic treatment. Consequently the previous studies which investigated or reviewed oral function and rehabilitation, and oral bacteria- or nutrition-related systemic diseases were included. Chewing ability is one of the most important dimensions not only of oral health but also of general health, because the ability to chew food may afect dietary choices and nutritional intake. However, there is a risk that improvement of mastication efciency leads to the dietary excess. Terefore, importance of the evaluation of oral function and occlusal rehabilitation, and role of prosthodontics on the nutrition and the overall health were discussed. In addition, this article described oral bacteria- and non communicable diseases, and provides basic knowledge of the nutrition for oral health. In conclusion, prosthodontic treatment should improve not only oral functions, but subsequently overall health. Terefore, dentist should aware not only of the primary endpoint but secondary endpoint.