www.ijapbc.com IJAPBC – Vol. 5(2), Apr - Jun, 2016 ISSN: 2277 - 4688 202 INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACY, BIOLOGY AND CHEMISTRY Research Article ABSTRACT The radiomodulatory effect of Aloe vera was studied in liver of Swiss albino mice. Animals were divided into two groups. Animals of group I administered Aloe vera (drug) and control set of group II were given radiation only where as animals experimental set of group II were administered by Aloe vera + Radiation. Histopathology was assessed at different intervals of post-irradiation from day ¼, and 1 post irradiation. Results suggest that Aloe vera modulate the radiation induced pathological alterations in Swiss albino mice. Keywords: Radioprotection, Aloe vera, Swiss albino mice, Histopathology. INTRODUCTION Various radioisotopes, gamma radiation and x-rays are being used considerably in medical sciences both for diagnostic and therapeutic purposes. Release of radioactive nuclides into atmosphere or ground water or both has increased due to underground testing of nuclear weapons. In industrial and technological areas growing applications of radiation have amazingly increased the risk for workers either by low dose exposure over a long term period or unpredictable accidental exposure. Nowadays exposure of cosmic radiation and background radiation are also increasing continuously. Radiation produces free radicals which are hazards for human beings. The potential application of radioprotective chemicals in the event of planned exposures or radiation accidents/incidents has been investigated. But successes of these chemical compounds are limited because of their high toxicity. Due to this various plant extracts and herbal preparations have been studied to have radio protective action in vivo and in vitro studies 1,2,3,4 . Since several thousands of year’s Aloe vera used medicinally, it belongs to Aloaceae family. It has rejuvenating, healing or smoothing properties. Aloe vera has two parts- latex and gel. Latex contain anthraquinone glycosides (Aloin, Aloe emodin) that are potent laxatives, laxative effect from Aloe is stronger than any other herb. Herbal medicine is still the mainstay of about 75-80% of the world population, mainly in the developing countries, for primary health care because of better cultural acceptability, better compatibility with the human body and lesser side effects. One such popularly known and used plant is Aloe vera barbadensis belonging to family Liliacae and consists of about more than 250 species. It is commonly called "Guar -patha" or Ghee-Kuar. It is rich in vitamin A, E, C and Zinc and Selenium. It is reported to have antioxidant, anti-tumor and anti- inflammatory activities. Liver is an important metabolic organ because it plays a key role in removing excess calcium, magnesium and iron internally and also important in food digestion. Therefore, this study was undertaken to evaluate the value of nutritional supplementation of Aloe vera against the radiation induced damage on the liver of Swiss albino mice. Evaluation the protective effect of Aloe vera against radiation induced hepatic toxicity in Swiss albino mice Priyanka Dadupanthi Department of Zoology, University of Rajasthan, Jaipur, India - 302004.