brain sciences Article Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder Atiqul Haq Mazumder 1, * , Jennifer Barnett 2 , Erkki Tapio Isometsä 3 , Nina Lindberg 3 , Minna Torniainen-Holm 4 , Markku Lähteenvuo 5,6,† , Kaisla Lahdensuo 6,7,† , Martta Kerkelä 1 , Ari Ahola-Olli 6 , Jarmo Hietala 8,9 , Olli Kampman 10,11 , Tuula Kieseppä 3,6,7,† , Tuomas Jukuri 1,6,† , Katja Häkkinen 5,6,† , Erik Cederlöf 4 , Willehard Haaki 6,8,† , Risto Kajanne 6 , Asko Wegelius 3,4,6,† , Teemu Männynsalo 6,12,† , Jussi Niemi-Pynttäri 6,12,† , Kimmo Suokas 6,10,† , Jouko Lönnqvist 4,13 , Jari Tiihonen 5,14,15 , Tiina Paunio 3,4,13 , Seppo Juhani Vainio 16,17,18,19 , Aarno Palotie 6,7,20,21,† , Solja Niemelä 8,9 , Jaana Suvisaari 4 and Juha Veijola 1,22   Citation: Mazumder, A.H.; Barnett, J.; Isometsä, E.T.; Lindberg, N.; Torniainen- Holm, M.; Lähteenvuo, M.; Lahdensuo, K.; Kerkelä, M.; Ahola-Olli, A.; Hietala, J.; et al. Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder. Brain Sci. 2021, 11, 1422. https://doi.org/ 10.3390/brainsci11111422 Academic Editor: Tomaso Vecchi Received: 22 September 2021 Accepted: 26 October 2021 Published: 27 October 2021 Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional afﬁl- iations. Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). 1 Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, 90014 Oulu, Finland; Martta.Kerkela@oulu.ﬁ (M.K.); Tuomas.Jukuri@oulu.ﬁ (T.J.); Juha.Veijola@oulu.ﬁ (J.V.) 2 Cambridge Cognition, University of Cambridge, Cambridge CB25 9TU, UK; jhb32@cam.ac.uk 3 Department of Psychiatry, University Hospital and University of Helsinki, 00029 Helsinki, Finland; erkki.isometsa@helsinki.ﬁ (E.T.I.); nina.lindberg@helsinki.ﬁ (N.L.); Tuula.kieseppa@hus.ﬁ (T.K.); asko.wegelius@ﬁmnet.ﬁ (A.W.); tiina.paunio@helsinki.ﬁ(T.P.) 4 Mental Health Unit, Finnish Institute for Health and Welfare (THL), 00271 Helsinki, Finland; minna.torniainen-holm@thl.ﬁ (M.T.-H.); erik.cederlof@thl.ﬁ (E.C.); jouko.lonnqvist@thl.ﬁ (J.L.); jaana.suvisaari@thl.ﬁ (J.S.) 5 Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, 70240 Kuopio, Finland; Markku.Lahteenvuo@niuva.ﬁ (M.L.); Katja.Hakkinen@niuva.ﬁ (K.H.); jari.tiihonen@ki.se (J.T.) 6 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland; kaisla.lahdensuo@icloud.com (K.L.); ari.ahola-olli@helsinki.ﬁ (A.A.-O.); hawker@utu.ﬁ (W.H.); risto.kajanne@helsinki.ﬁ (R.K.); teemu.mannynsalo@hel.ﬁ (T.M.); jussi.niemi-pynttari@hel.ﬁ (J.N.-P.); kimmo.suokas@tuni.ﬁ (K.S.); aarno.palotie@helsinki.ﬁ (A.P.) 7 Mehiläinen, Pohjoinen Hesperiankatu 17 C, 00260 Helsinki, Finland 8 Department of Psychiatry, University of Turku, 20014 Turku, Finland; jarmo.Hietala@tyks.ﬁ (J.H.); solnie@utu.ﬁ (S.N.) 9 Department of Psychiatry, Turku University Hospital, 20521 Turku, Finland 10 Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland; olli.kampman@tuni.fi 11 Department of Psychiatry, Pirkanmaa Hospital District, 33521 Tampere, Finland 12 Social Services and Health Care Sector, City of Helsinki, 00099 Helsinki, Finland 13 Department of Psychiatry, University of Helsinki, 00014 Helsinki, Finland 14 Department of Clinical Neuroscience, Karolinska Institute, 17177 Stockholm, Sweden 15 Center for Psychiatry Research, Stockholm City Council, 11364 Stockholm, Sweden 16 Infotech Oulu, University of Oulu, 90014 Oulu, Finland; seppo.vainio@oulu.ﬁ 17 Northern Finland Biobank Borealis, Oulu University Hospital, 90220 Oulu, Finland 18 Faculty of Biochemistry and Molecular Medicine, University of Oulu, 90014 Oulu, Finland 19 Kvantum Institute, University of Oulu, 90014 Oulu, Finland 20 Stanley Center for Psychiatric Research, The Broad Institute of MIT (Massachusetts Institute of Technology) and Harvard, Cambridge, MA 02142, USA 21 Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA 22 Department of Psychiatry, Oulu University Hospital, 90220 Oulu, Finland * Correspondence: atiqul.mazumder@oulu.ﬁ † 2016–2018. Afﬁliation during clinical study phase. Abstract: The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was Brain Sci. 2021, 11, 1422. https://doi.org/10.3390/brainsci11111422 https://www.mdpi.com/journal/brainsci