International Journal of Advances in Medicine | December 2020 | Vol 7 | Issue 12 Page 1789 International Journal of Advances in Medicine Kaur R et al. Int J Adv Med. 2020 Dec;7(12):1789-1794 http://www.ijmedicine.com pISSN 2349-3925 | eISSN 2349-3933 Original Research Article Study of demographic, hematological profile and risk stratification in chronic myeloid leukemia patients, in and around North-West Punjab, India Rajandeep Kaur 1 , Rajeev Gupta 1 *, Manish Chandey 1 , Parminder Singh 1 , Gurinder Mohan 1 , Navdeep Singh 1 , Shveta Mahajan 2 , Robin Kamboj 1 INTRODUCTION Chronic myelogenous leukaemia (CML) is a myeloproliferative disorder, characterized by clonal expansion of abnormal pluripotent haemopoietic stem cell, arising from reciprocal translocation of genetic material between long arms of chromosome 9 and 22. 1 The resulting BCR-ABL fusion gene is derived from translocation of abl gene on chromosome 9, which becomes juxtaposed to bcr gene on chromosome 22. 2 The BCR-ABL oncogene results in constitutive expression of an oncoprotein (p210) with tyrosine kinase activity, which causes activation of anti-apoptotic pathways and unregulated proliferation of stem cells resulting in expansion of myeloid cell mass.3 The disease undergoes clonal evolution from relatively stable chronic phase to an accelerated phase lasting for 4-6 months, and finally 1 Department of Medicine, SGRD Institute of Medical Sciences and Research, Amritsar, Punjab, India 2 Department of Oral Medicine and Radiology, Primary Health Care Centre, Lakhanpur, Punjab, India Received: 21 October 2020 Revised: 08 November 2020 Accepted: 09 November 2020 *Correspondence: Dr. Rajeev Gupta, E-mail: drrajeevgupta1@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background: Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder with cytogenic profile and tyrosine kinase inhibitors used as its therapy. Objective of the present study was to determine the demographic, haematological profile and to characterize them in low and high-risk group on presentation with European treatment and outcome study score (EUTOS) in CML patients in and around North-West Punjab, India. Methods: Diagnosed cases of CML were taken. Investigations were done. Molecular and cytogenetic studies were also done whenever required and with EUTOS patients were stratified and then treatment was individualized. Results: Total 100 patients were enrolled. The mean age of presentation of CML was 44.7 years with M:F ratio was 1:1. 20% cases were of Hindu religion and 80% cases were Sikh by religion. 68% cases from rural area and 32% cases were from urban area. 92 patients were in chronic phase, 5 patients in accelerated phase, and 3 patients were found in blast crisis phase. Out of total 100 cases, 32% cases were of high-risk group and 68% cases were of low-risk group on presentation according to EUTOS. Conclusions: Most CML patients in north west Punjab are young (31-40 years) with male: female ratio is 1:1. Majority of them were Sikh by religion and from rural area. Most of them presented in Chronic phase of the disease and with low-risk strata according to EUTOS. Conclusion is that most patients presents in early phase of disease, with anaemia, leucocytosis or splenomegaly. Keywords: Accelerated phase, Blast crisis, Chronic phase, Chronic myeloid leukaemia, European treatment and outcome study score DOI: https://dx.doi.org/10.18203/2349-3933.ijam20204999