International Journal of Medicinal Plants and Natural Products (IJMPNP) Volume 6, Issue 1, 2020, PP 22-27 ISSN 2454-7999 (Online) DOI: http://dx.doi.org/10.20431/2454-7999.0601005 www.arcjournals.org International Journal of Medicinal Plants and Natural Products (IJMPNP) Page 22 Anti-Toxic and Anti-Carcinogenic Activities of the Trunk Bark of Sarcocephalus Pobeguinii Ousmane Keita 1* , Huguette Agnaniet 2 , Rokia Sanogo 3 , Balla Dianka 4 1 Department of Biological engineering of Institute of Applied Sciences (ISA) -University of Sciences, Technics and Technologies of Bamako – Mali 2 Laboratory of Natural Products and Organometallic Synthesis (LASNSOM) - Faculty of Sciences of University of Sciences and Technics of Masuku. Franceville, Gabon. 3 Laboratory of Pharmacognosy of Faculty of Pharmacy - University of Sciences, Technics and Technologies of Bamako (USTTB) – Mali Laboratory of Networks and Telecommunications. Institute of Applied Sciences of the University of Sciences, Technics and Technologies of Bamako (USTTB) - Bamako, Mali. 1. INTRODUCTION Toxicity is the measure of a substance's ability to cause adverse and unhealthy effects on all life forms. It can be conducted on an animal, a bacterium or plant, or a substructure of an organism such as the liver [1, 2]. The toxicity assessment is based on adequate non-measurable or measurable studies. Depending on the duration of exposure of the organism to the administered substance, a distinction is made between acute toxicity, subacute or (short-term) toxicity, sub chronic toxicity and chronic toxicity [3]. Abstract : Background Sarcocephalus pobeguinii, because of these virtues, is used in food as well as in therapy. The works noted in the literature concern both total extracts or different organs demonstrating antimalarial, antibacterial, antibiotic and antioxidant properties. The evaluation of toxicity is based on adequate qualitative or quantitative studies. Toxicity can be assessed on epidemiological, experimental in vivo, in vitro and theoretical modelling studies. Objective The purpose of this study is to evaluate anti-toxic and anti-carcinogenic of trunk bark of Sarcocephalus pobeguinii. Method 10 g of powder from the trunk bark of Sarcocephalus pobeguinii was introduced in 100 mL. After lyophilization of the extract, the single dose of 2000 mg/kg of Sarcocephalus pobeguinii was administered to 5 male and female mice and their behaviour was observed for 1 day. The 0 mg/kg, 10 mg/kg, 50 mg/kg and 100 mg/kg doses of the extract were prepared and administered daily to 4 male and female rats per batch for 45 and 90 days. At the end of each experiment, the rats were sacrificed and ALT and AST levels were determined. Doses of 1 mg/kg and 0.5 mg/kg of the extract were tested in vitro on MCF-7 cancer cells. Results The mortality rate of 2000 mg/kg was 0%. The weight of female rats was decreased by 42.64% at 100 mg/kg. The increase in ALT activity at 50 mg/kg was 44.95% and 100 mg/kg (43.92%) while the increase in ALT activity was 59.68%. Percent survival of MCF-7 cells was 120% at 1 mg/kg. Conclusion Sarcocephalus pobeguinii is no toxic, no carcinogenic and requires further studies. Keywords : Sarcocepahalus pobeguinii, toxicity, cancer *Corresponding Author: Ousmane Kéita, Department of Biological engineering of Institute of Applied Sciences (ISA) -University of Sciences, Technics and Technologies of Bamako – Mali