Biomedical & Pharmacology Journal, June 2021. Vol. 14(2), p. 881-889 Published by Oriental Scientific Publishing Company © 2021 This is an Open Access article licensed under a Creative Commons license: Attribution 4.0 International (CC-BY). Relationship Between Immunity Level and Quality of Life among Housewives Living with HIV (Cross-sectional Study in Central Borneo, Indonesia) Nurhalina Nurhalina* and Faradila Faradila Departement of Health Science, Muhammadiyah University of Palangkaraya Indonesia, Indonesia. *Corresponding author E-mail: nurhalina.ahmadi123@gmail.com https://dx.doi.org/10.13005/bpj/2190 (Received: 10 February 2021; accepted: 29 June 2021) In Central Kalimantan Province, housewives constitute the second largest group of people with HIV (+) (19.4%) after the private group. Most of them (61.4%) reported on the poor quality of life, especially in the domain of psychology due to frustration and poverty. In its management, the intervention program has not fully integrated the life quality of people with HIV toward the accepted treatment model because of the lack of information about the case. Therefore, the particular study aims to find out the relationship between quality of life and the level of immunity of housewives with HIV (+), which expect to have benefited the development of a program for managing ODHA in Central Kalimantan Province. Cross-sectional study approach used in the research where the population is a housewife with HIV (+) who lives in Central Kalimantan Province. The purposive sampling technique used to select the sample with criteria of the subjects have a CD4 > 200 cell/µL and are excluded when experiencing psychiatric disorders and/or dying. There were 54 people as the sample. Data were analyzed bivariate using chi-square test and multivariate analysis with logistic regression. The results of statistical tests showed no significant relationship between quality of life and the level of immunity of participants in the physical domain (p = .2.071); psychological domain (p = 0.610); social domain (p = 0.595); environmental domain (p = 0.393); perception of health conditions (p = 0.317) and; perception of quality of life (p = 2.140).It needs further assessment toward the total number of CD4 before starting ART, treatment adherence, disease history and lifestyle of the participants. And, interventions can improve the quality of life and increase the immunity of participants Keywords: HIV/AIDS, Housewives, Level of immunity, PLWHA, , Quality of life. Indonesia has the 3rd largest prevalence of HIV infection in Asia Pacifc, with the annual rate of new cases reaching 16%. 1 In 2018, the cumulative number of people with HIV was 242,699 and those with AIDS was 87,453. Central Borneo is the largest province on the island of Borneo, Indonesia. Compared to other regions in the country, the HIV infection prevalence in this province is low, with a cumulative number of people with HIV at 810 in 2017. 2 Although the number of cases in the province is relatively small, there are particular challenges in dealing with HIV infection. The absence of donor agencies is an additional obstacle for peer support groups (PSG)