_____________________________________________________________________________________________________ *Corresponding author: E-mail: vinujay8@gmail.com; Journal of Pharmaceutical Research International 33(38B): 234-241, 2021; Article no.JPRI.71220 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Topical Application of Glycerine – Paraffin Combination in CKD-associated Pruritus and Uremic Xerosis: Study Protocol for a Randomized Control Trial Veena Verma 1* , Meenakshi Yeola 2 and Ruchira Ankar 3 1 Department of Medical Surgical Nursing, Government College Of Nursing Raipur, Pt. Deendayal Upadhyay Memorial Health & Aayush University Chhattisgarh, India. 2 Department of Surgery, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra, India. 3 Department of Medical Surgical Nursing, Srimati Radhikabai Meghe Memorial College of Nursing, Sawangi (Meghe),Wardha, Maharashtra, India. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2021/v33i38B32119 Editor(s): (1) Prof. John Yahya I. Elshimali, UCLA School of Medicine & Charles R. Drew University of Medicine and Science, USA. Reviewers: (1) Guilherme Muzy, ABC Foundation School of Medicine, Brazil. (2) Shatha Hussain Ali, Al-Nahrain University, Iraq. Complete Peer review History: https://www.sdiarticle4.com/review-history/71220 Received 15 May 2021 Accepted 18 July 2021 Published 28 July 2021 ABSTRACT Background: Chronic kidney disease associated pruritus (CKD-ap) and xerosis is intensely annoying and unpleasant manifestations associated with maintenance renal dialysis (MRD) among chronic kidney disease (CKD) patients. It severely compromises the quality of life by disturbing normal sleep pattern and also adversely affect the mental health in CKD patients. Many proposed treatment plan for CKD –ap is tested but none of the treatment plan provide complete relief from itch associated with MRD. Glycerine accelerate barrier repair and also has rapid hydrating and smoothing effect while Paraffin preserve the barrier function against irritant. As a comparator Mustard oil is used as it is commonly used home remedy by people in Indian sub-continent for dry skin. Study Protocol