de Brito et al. J Brain Disord 2017, 1(1):38-43 Copyright: © 2017 de Brito MR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Research Article Open Access Journal of Brain Disorders • Page 38 • *Corresponding author: Antônio Eiras Falcão, Department of Surgery, Faculty of Medical Sciences, State University of Campinas (Unicamp), Tessália Viera de Camargo St. 126, University Town, Zeferino Vaz, Zip Code 13083-887, Campi- nas, São Paulo, Brazil, Tel: +55-(19)-3521-9450, Fax: +55- (19)-3521-8043, E-mail: aefalcao@gmail.com Received: August 29, 2017; Accepted: October 14, 2017; Published online: October 16, 2017 Citation: de Brito MR, de Almeida Barros AG, Valler L, et al. (2017) Evaluation of Sequential Organ Failure Assessment (SOFA) Performance in Neurocritical Care Patients Overtime: A Retrospective Cohort Study. J Brain Disord 1(1):38-43 ISSN: 2578-6571 | DOI: 10.36959/524/329 | Volume 1 | Issue 1 Evaluation of Sequential Organ Failure Assessment (SOFA) Performance in Neurocritical Care Patients Overtime: A Retrospective Cohort Study Mariana Rabelo de Brito 1 , Alexandre Guimarães de Almeida Barros 2 , Lenise Valler 1 , Fabricio Buchdid Cardoso 1 , Ana Paula Devite Cardoso Gasparotto 2 , Luciana Tiziani Silva 2 , Cristina Bueno Terzi Coelho 2 , Desanka Dragosavac 2 and Antônio Eiras Falcão 2 * 1 Department of Neurology, Faculty of Medical Sciences, State University of Campinas (Unicamp), Campinas, São Paulo, Brazil 2 Department of Surgery, Faculty of Medical Sciences, State University of Campinas (Unicamp), Campinas, São Paulo, Brazil Abstract Prediction models are widespread used as surrogate markers of disease severity, benchmarking and resource allocation in critical care. Afer derivation, they should pass through validation in diferent settings before their general use in other populations. Moreover, constant assessment of score’s performance is necessary to keep them reliable. In this study, we sought to evaluated Sequential Organ Failure Assessment (SOFA) score discrimination and calibration for mortality in a cohort of neurosurgical and neurological patients overtime. Although SOFA showed a good discrimination in all timepoints, our data suggest that its calibration may improve as time pass. Terefore, SOFA is a good model for mortality prediction in neurological and neurosurgical patients and may help for organ dysfunction objective evaluation and benchmarking in neurocritical care. Keywords Neurocritical care, Severity scores, SOFA, Critical care medicine used and studies support their reliability for mortality pre- diction in general ICUs [6,8]. SOFA is a score initially pro- posed for organ dysfunction quantifcation in general criti- cally ill patients, that was posteriorly validated for mortality prediction as well [4,9,10]. Studies have shown that values calculated using original SOFA score or composites of it, Introduction Admission to intensive care units is a critical decision for many patients [1]. Tis is because of the great burden for the patient and family regarding the equilibrium among real benefts and harms cause by it [1,2]. Moreover, critical care is associated with elevated costs for healthcare systems that may increase as therapeutics evolve. Terefore, mod- els that aid for an objective evaluation of endpoints in this setting, allowing to an evidence-based decision process and management, are important to pursue. In this context, pre- dictive scores appear as tools for outcome prediction, sever- ity of illness evaluation, comparison among reference stan- dards, and resource allocation [3-7]. Several scores are available for general critical care pa- tient’s stratifcation. Among them, Acute Physiology and Chronic Health Disease Classifcation System (APACHE) II, Simplifed Acute Physiology Score (SAPS) 3 and Sequen- tial Organ Failure Assessment (SOFA) have been widely