_____________________________________________________________________________________________________ *Corresponding author: E-mail: savasgokturk@yahoo.com; International Research Journal of Gastroenterology and Hepatology 3(1): 37-41, 2020; Article no.IRJGH.53848 A Randomized Controlled Trial of Anoscopy and Manual Abdominal Compression to Increase Patient Comfort after Colonoscopy Gulhan Kanat Unler 1 , Huseyin Savas Gokturk 1* and Aydın Karakoca 2 1 Department of Gastroenterology, Faculty of Medicine, Baskent University, Konya, Turkey. 2 Department of Statistics, Faculty of Science, Necmettin Erbakan University, Konya, Turkey. Authors’ contributions This work was carried out in collaboration among all authors. Author GKU designed the study, wrote the first draft of manuscript. Author HSG Managed the analysis of the study and wrote the last draft of manuscript. Author AK Performed the statistical analysis. All authors read and approved the final manuscript. Article Information Editor(s): (1) Dr. Renato Borges Fagundes, Professor, Department of Clinical Medicine, Federal University of Santa Maria (RS), Brazil. Reviewers: (1) Michael Bordonaro, Geisinger Commonwealth School of Medicine, USA. (2) Jai Singh, Oswego Hospital and SUNY Upstate Medical University, USA. (3) Jung Hun Choi, Georgia Southern University, Georgia. Complete Peer review History: http://www.sdiarticle4.com/review-history/53848 Received 15 November 2019 Accepted 17 January 2020 Published 27 January 2020 ABSTRACT Background/Aim: Colonoscopy may be associated with pain due to distension of colonic mesentery and air insufflation into the colonic lumen, although Sedo-analgesia may increase the tolerability of the procedure. This randomized, prospective, controlled study based on our clinical observations aimed to explore the sustainability of comfort provided by intraoperative sedation by allowing gas discharge via anoscopy while patients were still sedated. Methods: The patients that underwent colonoscopy for colorectal cancer screening were considered for this study and a total of 100 patients were (61 male and 39 female) were included in this study. Colonoscopy procedures were carried out by two experienced endoscopists who are adequately trained. Following the colonoscopy, 50 patients in the study group were administered a disposable anoscope with sterile, water-soluble, lubricant gel while the effect of sedation was still maintained. Endoscopist compressed four abdominal quadrants for 5 seconds to evacuate gas and Original Research Article