 Corresponding author: Volkan Gelen Department of Physiology, Veterinary Faculty, Kafkas University, Kars, Turkey. Copyright © 2021 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0. Protective effects of resveratrol on kidney function tests and renal histopathology in carbon tetrachloride-induced renal toxicity in rats Volkan Gelen 1, * and Emin Şengül 2 1 Department of Physiology, Veterinary Faculty, Kafkas University, Kars, Turkey. 2 Department of Physiology, Veterinary Faculty, Ataturk University, Erzurum, Turkey. World Journal of Advanced Research and Reviews, 2021, 10(01), 156–161 Publication history: Received on 10 March 2021; revised on 13 April 2021; accepted on 15 April 2021 Article DOI: https://doi.org/10.30574/wjarr.2021.10.1.0155 Abstract In this study, it was aimed to investigate the protective effect of Resveratrol, which has a strong antioxidant effect on kidney tissues of rats experimentally induced with carbon tetrachloride with nephrotoxicity, by kidney function tests and histopathology. For this purpose, 32 male Wistar Albino rats were used. The subjects were randomly selected, 1 st group control, 2 nd group CCl4, 3 rd group Resveratrol. The 4 th group was divided into 4 groups as CCl4 + Resveratrol. At the end of the experiment, animals were sacrificed under anesthesia and kidney samples were taken in 10% formalin solution for histopathological analysis. In the histopathological examination, it was found that the rats in the control and Resveratrol groups had normal kidney histological structure. In CCI4 group, severe hydropic degeneration in tubules epithelium, mild coagulation necrosis in tubules epithelium and severe hyperemia in the vessels were observed. When kidney tissues of rats were examined in CCI4 + Resveratrol group, mild hydropic degeneration in tubules epithelium and mild hyperemia in vessels were observed. When the kidney tissues of the rats in the Resveratrol group were examined, it was observed that they had a normal histological appearance. As a result, it was determined that Resveratrol has a protective effect on kidney damage caused by CCI4. Keywords: Kidney; CCI4; Rat; Resveratrol; Urea 1. Introduction Carbon tetrachloride (CCl4) is a fast evaporating, colorless, non-flammable and fragrant chemical. Since CCl4 does not occur naturally, it is produced chemically [1]. CCl4 can be ingested largely by inhalation as well as swallowing and skin [2]. Since CCl4 is a good chemical solvent, it is used as an organic solvent in industrial areas, in obtaining seed extracts, in the synthesis of heat transfer element in cooling equipment, in oils, pesticide products, petroleum products. It is stated that those living close to textile and chemical factories, pesticide (pesticide) applicators, those working in waste centers, dry cleaners are exposed to CCl4 and are at great risk [1,3,4]. If the CCl4 level in the body exceeds certain levels, an increase in oxidative stress and consequently serious damage to components such as protein, lipid and nucleic acid in the cell occurs [5]. It has been determined as a result of studies that CCl4 causes organ toxicities in tissues such as liver [6], heart [7], brain [8] and kidney [9]. In various recent studies, some flavonoids and natural ingredients are used to prevent the harmful effects of some toxic substances on the organs [10-29]. One of these substances is resveratrol. Resveratrol is a polyphenolic compound with many positive effects on health, especially since 1997. In addition to its anti-carcinogenic, anti-inflammatory, neuroprotective, anti-atherogenic, anti-thrombogenic and anti-liver fatty effects, it has been reported to increase insulin sensitivity and prolong life expectancy [30]. Resveratrol is especially abundant in the content of black mulberries, grapes and red wine [31]. The protective and therapeutic effects of resveratrol in nephrotoxicity models induced by various chemicals have been determined by many studies [32-34]. In the light of