American Journal of Chemistry and Application 2018; 5(4): 58-63 http://www.aascit.org/journal/ajca ISSN: 2375-3765 Synthesis and Study of Antioxidant Activities of trans-(-)-Clovamide Derivatives Serigne Omar Sarr 1, *, † , Abdoulaye Gassama 2, † , Françoise Manga 1 , Fabienne Grellepois 3 , Catherine Lavaud 3 1 Faculté de Médecine et de Pharmacie, Université Cheikh Anta DIOP, Dakar, Sénégal 2 Faculté des Science et Technologies, Université Assane Seck, Ziguinchor, Sénégal 3 Institut de Chimie Moléculaire de Reims, Université de Reims, Reims, France Email address * Corresponding author † Serigne Omar Sarr and Abdoulaye Gassama are co-first authors Citation Serigne Omar Sarr, Abdoulaye Gassama, Françoise Manga, Fabienne Grellepois, Catherine Lavaud. Synthesis and Study of Antioxidant Activities of trans-(-)-Clovamide Derivatives. American Journal of Chemistry and Application. Vol. 5, No. 4, 2018, pp. 58-63. Received: April 6, 2018; Accepted: May 2, 2018; Published: June 1, 2018 Abstract: A peptide coupling reaction between L-phenylalanine (L-DOPA) and cinnamic acids derivatives has been successfully employed for the synthesis of a set of small molecules derived from trans (-) clovamide. The antioxidant activity of these derivative molecules is reported. The antioxydant and antiradical activity were determined using DPPH (2-2-Diphenyl picrylhydrazyl) radical. The molecules which exhibit interesting antioxidant activity were: compound 5 (IC 50 =3.46±0.034µg/ml); compound 6 (IC 50 =3.04±0.01 µg/ml); compound 7 (IC 50 =4.23±0.02 µg/ml); compound 8 (IC 50 =5.1±0.061 µg/ml); compound 9 (IC 50 =1.55±0.17 µg/ml); compound 10 (IC 50 =6.02±0.07 µg/ml) and compound 13 (IC 50 =2.49±0.06 µg/ml). These molecules contain polyphenols wich are generally very good antioxidants. Thus, this study showed that compound 9 with an IC 50 of 1.55 µg/ml has antioxidant activity close to that of quercetin (IC 50 = 1.20µg/ml), a well known antioxidant compound. Keywords: Antioxidant, Antiradical, trans-(-)-Clovamide, DPPH 1. Introduction Oxidative stress is involved in the development of many pathologies as a triggering factor or associated with complications. Most of the diseases induced by oxidative stress appear with age because aging decreases antioxidant defenses and increases the mitochondrial multiplication of radicals [1]. Oxidative stress is the primary cause of several diseases [2]. It is the factor potentiating the appearance of multifactorial diseases such as type 2 diabetes, Alzheimer's disease, obesity, rheumatism, atherosclerosis, cancers and cardiovascular diseases [3-4]. The concept of an antioxidant therapy, with the aim of strengthening the endogenous antioxidant defense for a more effective protection against oxidative stress, represents an important therapeutic issue of scientific and public interest. From molecules isolated from plants, it is possible to modulate their pharmacological activities by different structural modifications by hemi- synthesis or total synthesis. It is in this context that our study aimed at evaluating the antioxidant activity of nine synthetic molecules. We report the synthesis of molecules derived from trans (-) clovamide [5-7], which we isolated in the leaf of Icacina olivifomis (Poiret) Raynal and the experimental study of their antioxidant activities. Icacina oliverfomis (Poiret) Raynal also known as I. senegalensis is a traditional Senegalese medicinal plant which leaves are used in Senegal for the treatment of diabetes [8] and other diseases [4]. 2. Materials and Methods 2.1. Molecules Studied The molecules which antioxidant activity were evaluated consisted of synthetic substances derived from trans (-)