_____________________________________________________________________________________________________ *Corresponding author: E-mail: bharatrathi174@gmail.com; Journal of Pharmaceutical Research International 33(31B): 54-60, 2021; Article no.JPRI.68585 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Comparative Pharmaceutical Standardization and Oral Bioavailability Study on Praval Pishti and Praval Bhasma Megha Satpute 1 , Bharat Rathi 1* , Anita Wanjari 1 and Mujahid Khan 1 1 Department of Rasashastra and Bhaishajya Kalpana, Mahatma Gandhi Ayurveda College Hospital and Research Centre, Salod (H) Wardha, (MS), Datta Meghe Institute of Medical Sciences (Deemed to be university) Wardha, (MS), India. Authors’ contributions This work was carried out in collaboration among all authors. Author MS designed the study, performed the statistical analysis, wrote the protocol and wrote the first draft of the manuscript. Author BR managed the analyses of the study and the literature searches. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2021/v33i31B31690 Editor(s): (1) Dr. Jongwha Chang, University of Texas, USA. Reviewers: (1) Tripti Malik, Dolphin PG Institute of Biomedical & Natural Sciences, India. (2) Jaideep Sarkar, KHPL, India. Complete Peer review History: http://www.sdiarticle4.com/review-history/68585 Received 20 March 2021 Accepted 27 May 2021 Published 12 June 2021 ABSTRACT Background: Praval (coral) is a very usually occurring calcium form. It is rich source of calcium & minerals. As per text it can be converted into two formulas which are bhasma (calcinated ash) and pishti(powdered form without agni).These forms may have different rate of immersion. This needs to be studied. Aim: Pharmaceutical Standardization study of Praval Pishti & Praval Bhasma and comparative evaluation of their relative oral bioavailability. Materials and methods: The two formulations will be prepared from Praval (coral). By triturating with Gulab jala Praval Pishti will be prepared and by traditional Puta method Praval Bhasma will be prepared. The prepared formulations will be assessed for Bhasma Pariksha mentioned in Ayurveda. Organoleptic characters, Physicochemical parameters and Particle size distribution analysis, SEM –EDX (Scanning Electron Microscopy, Energy Dispersive X-Ray Analysis), FTIR (Fourier-transform infrared spectroscopy), XRD (X-Ray Diffraction), and GCMS (Gas Study Protocol