Keywords: Carbamylation, Catechin, Morin, Myricetin, Kaempferol, Luteolin, Naringin, LDL doi:10.1016/j.clinbiochem.2011.08.182 E Poster – [A-10-591-1] Changes of urinary iodine and thyrotropin during pregnancy in an iodine deficient area Beiranvand Asghar a , Rostami Rahim a , Salarilak Shaker b , Aghassi Mohammad Reza a , Khalkhali Hamid Reza a , Nouroozzadeh Jafar a a Medical Faculty, Naslu-Urmia, West Azarbaijan, Iran b Medicine Faculty, Azad University, Tabriz, East Azarbaijan, Iran E-mail addresses: beiranvand83@yahoo.com (B. Asghar), rostamirahim@yahoo.com (R. Rahim), salarilak@yahoo.com (S. Shaker), mraghassi@yahoo.com (A.M. Reza), hamid_rekh@yahoo.com (K.H. Reza), jnouroozzadeh@yahoo.co.uk (N. Jafar) Introduction: Iodine is an essential component for proper thyroid function. In addition, its adequate availability during pregnancy is highly important for normal brain development of the fetus. Urinary iodine excretion (UIE) and thyrotropin (TSH) are indices of iodine intake and thyroid function. To assess iodine intake (I/Cr ratio) and thyroid function of pregnant women in Urmia city—West Azarbaijan province. Methods: 1078 pregnant women, referred to their 1st planned care, were interviewed at health centers (urban and amp; rural parts). Of these, 490 subjects were enrolled. Sera and urine samples were collected at two stages (1st and amp; 3rd trimesters). Urinary iodine excretion (UIE), urinary creatinine(Cr), TSH, and thyroproxidase antibody(TPO Ab) were measured. Results: Median I/Cr ratio was lower at 1st trimester than at 3rd trimester (46.4 vs.113.4, p< 0.0001). Mean(SD) of TSH(log-transformed) was lower at 1st trimester than at 3rd trimester also ( -0.15(0.48) vs. 0.23(0.32) IU/mL, p<0.001). The respected values for TPO Ab were 0.38 (0.94) and 0.25(0.79) IU/mL in order which showed significant increase (p<0.001). Subjects with positive TPO Ab were 10% at 1st trimester which reduced to 5% at 3rd trimester. Conclusion: our data reveals that a mild-moderate iodine deficiency is present among pregnant women in Urmia. The figures for TSH at the 1st trimester emphasize the need for a definitive reference range of TSH. Further studies are needed to address the reasons for the low iodine despite two decades after salt enrichment in Iran. Keywords: Iodine, TSH, Pregnancy, TPO antibody doi:10.1016/j.clinbiochem.2011.08.183 E Poster – [A-10-621-1] Effect of tomato juice on serum concentrations of IL-6, IL-8, CRP and TNF-α in female students' overweight or obese dormitory of Tehran University of Medical Sciences Ghavipour Mahsa, Saedi Ahmad, Djallali Mahmoud, Eshraghiyan Mohammad Reza School of Public Health, Tehran University of Medical Sciences, Iran E-mail addresses: mahsaghavipour@yahoo.com (G. Mahsa), a_saedi@tums.ac.ir (S. Ahmad), jalalimahmoud@hotmail.com (D. Mahmoud), Eshraghiyan@yahoo.com (E.M. Reza) Introduction: the tomato and its products are the richest source of lycopene (the most powerful antioxidant among the carotenoids, and an anti-inflammatory factor). Since overweight and obesity increase the risk of inflammation and inflammatory diseases, this study is associated with the effect of tomato juice on serum concentrations of IL-6, IL-8, hsCRP, and TNF-α in overweight female students' weight or obese Tehran University dormitory. Method: In a clinical trial 118 overweight or obese individuals were chosen among female students at the dormitory of Tehran Medical Sciences University, and randomly selected 59 groups of people under control and intervention groups. The intervention group, received 300 ml of tomato juice (37 mg lycopene per day) to 20 days. Before and after the intervention period serum concentrations of hsCRP, IL-6, IL-8 and TNF-α in the two groups were compared. Results: Serum concentrations of IL-8 in the intervention group (from 129.26 to 119.35) was significantly decreased and in the control group (from 127.56 to 133.96) was increased. The difference in concentrations of IL-8 (intervention group: 9.91 and controls: 6.39) and TNF-α (intervention group: 8.25 and control group: 0.35) before and after intervention in both groups was significant. Changes in other variables were not significant. Discussion: The findings indicate that tomato juice may reduce inflammation in overweight and obese effectively. Keywords: Lycopene, Inflammatory biomarkers, Obesity, Inflammation doi:10.1016/j.clinbiochem.2011.08.184 E Poster – [A-10-708-3] The effect of sour cherry juice on total antioxidant activity and testosterone concentrations in cigarette smoking men Khadem Ansari Mohammad Hassan a , Shirpoor Rasool b , Rasmi Yousef a , Shasavari Zahra a a Faculty of Medicine, Urmia University of Medical Science b Payame Noor University Tehran E-mail addresses: mhansari1@hotmail.com (K.A.M. Hassan), pnu.hagh2@yahoo.com (S. Rasool), rasmiy@umsu.ac.ir (R. Yousef), z.shahsavari@yahoo.com (S. Zahra) Introduction: Antioxidants are important groups of chemical compounds that protect body against destructive factors such as free active radicals resulted from food metabolism. To encounter by these destructive factors, body system produce some antioxidants like enzymes and hormones and some other antioxidants through regimen. Examination of sour cherry juice effect on Total Antioxidants (TAC) and testosterone hormone secretion in men addicted to smoking cigarettes and its comparison with addicted men without taking juice were studied. Method and materials: For measuring TAC, method by the use of Randox kit is applied and for testosterone measurement, direct competitive method of luminance (solid phase) by using Liasian , an automatic system, is employed.. Towenty five volunteers of male employes of Shadlee Company addicted to smoking cigarettes were registered and received 2 glasses ≈300 cc concentrated sour cherry juice daily, for one month, and also 25 persons of company's employees that also smoking cigarettes were chosen as a control group that they did not use sour cherry juice. After a month, five milliliter blood were taken and serum after 15 minutes centrifuge in room temperature is isolated for examination. Results: This research shows that drinking 300 cc sour cherry juice daily has a positive effect on TAC in people who addicted to smoking cigarettes(Pvalve = 0.000) but no significant change in testosterone hormone were observed. There is no significant changes in TAC and testosterone in control groups. Conlusion: Sour cherry shows increase in TAC level in cigarette smoking men but no effect on testosterone level. Abstracts S81