© 2018. Antonella Márcia Mercadante de Albuquerque do Nascimento, Rosane Mansan Almeida, Inês Jorge Sequeira & Yanna Karla de Medeiros Nobrega. This is a research/review paper, distributed under the terms of the Creative Commons Attribution- Noncommercial 3.0 Unported License http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Global Journal of Medical Research: F Diseases Volume 18 Issue 4 Version 1.0 Year 2018 Type: Double Blind Peer Reviewed International Research Journal Publisher: Global Journals Online ISSN: 2249-4618 & Print ISSN: 0975-5888 hsCRP and E-Selectin as Markers of Endothelial Dysfunction in Children with Type 1 Diabetes Mellitus By Antonella Márcia Mercadante de Albuquerque do Nascimento, Rosane Mansan Almeida, Inês Jorge Sequeira & Yanna Karla de Medeiros Nobrega University of Brasilia Abstract- Introduction: This study investigated the levels of inflammatory biomarkers in healthy children and those diagnosed with type 1 diabetes (T1DM), some of whom were affected by endothelial dysfunction (ED), characterized by increased inflammation and reduced vasodilatation. Methods: Thirty-one T1DM children showing no symptoms of vascular diseases and diagnosed by ultrasound techniques as ED-positive (T1DM-ED) or negative (T1DM), and 58 sex-age-matched healthy children were investigated for circulating levels of E-selectin, s-ICAM and s-VCAM, MMP-9, high-sensitivity C-reactive protein (hsCRP), and IL-6. Results: No differences were observed in s-ICAM, MMP-9, and IL-6 levels between case and control groups. Significantly higher levels of s-VCAM (p= 0.0001) were found in the T1DM (1359.1 ± 273 ng/mL) and T1DM-ED (1358.2 ± 112 ng/mL) groups; (control - 828.5 ± 212 ng/mL). Higher levels of E-selectin (p = 0.001) were found in the T1DM-ED group (331.2 ± 77 ng/mL); (control - 222.2 ± 74 ng/mL). The values of hsCRP were higher (p = 0.002) in the T1DM-ED group (0.36 ± 0.2 mg/L) relative to control (0.15 ± 0.1 mg/L) and T1DM (0.19 ± 0.2 mg/L). The results suggest that E-selectin and hsCRP can be useful markers of ED in children with T1DM. Keywords: type 1 diabetes mellitus, children, endothelial dysfunction, markers, E-selectin, hsCRP. GJMR-F Classification: NLMC Code: WD 200.5.G6 hsCRPandEselectinasMarkersofEndothelialDysfunctioninChildrenwithType1DiabetesMellitus Strictly as per the compliance and regulations of: