Amritpal Singh et al JMSCR Volume 05 Issue 07 July 2017 Page 25592 JMSCR Vol||05||Issue||07||Page 25592-25596||July 2017 To Study the Pattern of Adverse Drug Reaction Due to Cancer Chemotherapy in Regional Cancer Centre of a Tertiary Care Teaching Hospital in West Rajasthan Authors Amritpal Singh 1 , R.P.Acharya 2 , Rajvinder Kaur 3 1 M.D. Pharmacology (3 rd year), 2 Sr.Prof. and Head, Department of pharmacology, S.P.M.C. Bikaner 3 District Hospital Ganganagar Corresponding Author Amritpal Singh Email: dr_amritpal@rediffmail.com Abstract Background: Cancer, a term that elicits a shock in the nerve endings of every individual touches every country in the world. Material and Method: It was a prospective observational study. The study was carried out between November 2015 to April 2016 conducted in medical Oncology & Radiation Oncology Department in P.B.M. hospital and associated group of hospital, Bikaner. Result: female 43(252) were more affected by ADR as compared to male patients 34 (164). anaemia (14.42%) was the most common ADR followed by Vomiting (10.34%) and Nausea (9.13%). Conclusion: Chemotherapeutic drugs have a narrow therapeutic index and the dosage needed to achieve a therapeutic response usually proves toxic to the body’s rapidly proliferating cells. Keywords: ADRs, Cancer, Chemotherapy. Introduction Cancer, a term that elicits a shock in the nerve endings of every individual touches every country in the world. 1 Cancer incidences and death rates are rapidly increasing world widely as well as in India. 2 According to Global Cancer Network (GLOBOCAN) 2012 report, an estimated 14.1 million new cancer cases and 8.2 million cancer- related deaths occurred in 2012. Prevalence estimates for 2012 show that there were 32.6 million people alive who had cancer diagnosed in the previous five years. The prevalence of cancer is expected to increase, it has been estimated that by the year 2030, there will be 22.2 million new cancer cases and over 13.1 million cancer deaths will occurs annually in the world. 4 Cancer chemotherapy first introduced in the 1960s, before that surgery and radiation therapy was the only means of cancer treatment. 14 Chemotherapeutic drugs have a narrow therapeutic index and the dosage needed to achieve a therapeutic response usually proves toxic to the body’s rapidly proliferating cells. 16 Adverse drug reactions (ADRs) are any noxious, unintended and undesired effects of a drug which www.jmscr.igmpublication.org Impact Factor 5.84 Index Copernicus Value: 83.27 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v5i7.211