_____________________________________________________________________________________________________ *Corresponding author: E-mail: mahama.ouattara@univ-fhb.edu.ci, mahama.dpm@gmail.com; Chemical Science International Journal 30(6): 10-21, 2021; Article no.CSIJ.70639 ISSN: 2456-706X (Past name: American Chemical Science Journal, Past ISSN: 2249-0205) New Biological Targets in Fungi and Novel Molecule under Development: A Review Songuigama Coulibaly 1 , Jean-Paul D. U. N'guessan 1 , Alain Kacou 1 , Jean-Fabrice K. Koffi 1 , Amelanh S. Diakité 1 , Tanguy K. A. Kouaho 1 and Mahama Ouattara 1* 1 Département de Chimie Thérapeutique et Chimie Organique, UFR Sciences Pharmaceutiques, Université FHB, 01 BP V34 Abidjan, Côte d’Ivoire. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/CSJI/2021/v30i630235 Editor(s): (1) Prof. Dimitrios P. Nikolelis, Athens University, Greece. Reviewers: (1) S. Murugesan, University of Madras, India. (2) Maria Bintang, Bogor Agricultural University, Indonesia. Complete Peer review History: https://www.sdiarticle4.com/review-history/70639 Received 30 April 2021 Accepted 10 July 2021 Published 13 July 2021 ABSTRACT Antifungal therapeutics is confronted today with the challenge of drug resistance of most fungal germs to current antifungal drugs. Faced with this situation, the search for new and more efficient antifungal molecules that avoid the phenomenon of drug resistance becomes an urgent task. The design of new antifungal drugs acting on new biological targets and/or by innovative mechanisms of action is essential in the fight against fungal infections. Current advances in molecular biology have identified new targets for the development of new antifungal therapy. Several biological targets for the development of new antifungal agents are currently being explored. Amongst these, the most promising are BET (Bromodomain and Extra-Terminal) proteins, Homoserine transacetylase (HTA), mannan cell wall, Glycosylphosphatidylinositols (GPI) anchor biosynthesis, Histone deacetylases, Sphingolipid biosynthesis, D9 fatty acid desaturase and Chitin biosynthesis. This review summarizes the new biological targets and their inhibitors under development as potential new antifungal drugs. Review Article