Available on line www.jocpr.com Journal of Chemical and Pharmaceutical Research __________________________________________________ ISSN No: 0975-7384 J. Chem. Pharm. Res., 2010, 2(2): 112-117 112 Synthesis and biological evaluation of anti-tubercular activity of some synthesised pyrazole derivatives Ravi G Patel*, Chirag K Patel, Vimal I Patel, D. J. Sen, B. Panigrahi and C. N. Patel Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Arvind Baug, Mehsana, Gujarat, India ______________________________________________________________________________ Abstract In the development of organic therapeutic agents, pharmaceutical scientists have explored numerous approaches in finding and developing organic compounds that are now available to us in dosage forms suitable for the treatment of our ills and often for the maintenance of our health. The present work deals with evaluation of anti-tubercular activity of various aldehyde derivatives synthesized by Claisen-Schmidt condensation method. The formation of pyrazole derivatives by reaction with phenyl isothiocyanate was also attempted. The synthesized derivatives were screened for anti-tubercular activity and the compounds demonstrated some remarkable features to be actively considered as anti-tubercular drugs. Keywords : Pyrazolines, antimycobacterial agents. ______________________________________________________________________________ Introduction Tuberculosis, one of the oldest diseases known to affect humans, is caused by bacteria belonging to the Mycobacterium tuberculae complex, an acid-fast aerobic bacillus. It is estimated that today one-third to one-half of the world population is infected with Mycobacterium tuberculae leading to approximately 6% of all death worldwide. Tuberculosis is the leading worldwide cause of mortality resulting from an infectious bacterial agent. Mycobacterium tuberculae is transmitted primarily via the respiratory route. Tuberculosis is a disease, which mainly affects the lungs (80-85% of the case); although in up to one-third of cases other organs are involved. It is the most frequent cause of death worldwide due to single infectious agent, and in 1993 WHO declared Tuberculosis as a global public health emergency. The physician is greatly challenged to provide optimal therapy for Mycobacterial illness because of the advent of AIDS, the increase in both drug-susceptible and multidrugresistant tuberculosis,