Int J Reprod BioMed Vol. 16. No. 11. pp: 719-722, November 2018 Short communication Investigation of anti-mullerian hormone (AMH) level and ovarian response in infertile women with endometriosis in IVF cycles Leili Safdarian M.D., Seyedeh Noushin Ghalandarpoor Attar M.D., Ashraf Aleyasin M.D., Marzieh Aghahosseini M.D., Fateme Sadaf Sarfjoo M.D., Sedigheh Hosseinimousa M.D. Department of Obstetrics and Gynecology, Infertility Unit, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Corresponding Author: Sedigheh Hosseinimousa, Department of Obstetrics and Gynecology, Infertility Unit, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Postal Cod: 1411713135. Email: hoseinimosa@sina.tums Tel: (+98) 9128186934 Received: 18 March 2018 Revised: 5 April 2018 Accepted: 20 June 2018 Abstract Background: Endometriosis, can cause ovarian conflict and reduced ovarian reserve that could lead to lower response to assisted reproductive techniques Objective: Current study was conducted to determine the association between level of anti-mullerian hormone (AMH) and the infertility treatment outcomes in infertile females with endometriosis versus the non-endometriosis infertile subject. Materials and Methods: In this case-control study, 64 infertile females who referred to Shariati Hospital from April 2015 to November 2017 were enrolled. They were divided in two groups of 32 patients (endometriosis and non-endometriosis women). The anti-mullerian hormone level among all subjects was determined, treatment outcomes were evaluated and association between these factors was assessed. Results: It was seen that the anti-mullerian hormone (p=0.06), the number of retrieved oocytes (p=0.7) and embryos (p=0.7), implantation rate (p=0.6) and clinical pregnancy rate (p=0.9) were similar between two groups. In patients with stage 3 or 4 endometriosis who had lower serum AMH level significantly (p=0.001) less oocytes were retrieved (p=0.001) and less transferrable embryos (p=0.03) were achieved. However, implantation and pregnancy rates did not differ (p=0.7) (p=0.6). Conclusion: Totally, according to the obtained results, it may be concluded that ovarian reserve has more significant role in predicting infertility treatment outcome rather than receptive endometrium. Key words: Endometriosis, Infertility, Anti-mullerian hormone. This article extracted from Ph.D. Thesis. (Seyedeh Noushin Ghalandarpoor Attar) Introduction t seems that in patients with endometriosis, especially in severe cases because of ovarian conflict and reduced ovarian reserve, Anti-Mullerian Hormone (AMH) level could be reduced that could lead to lower response to assisted reproductive techniques (ART) (1, 2). But previous studies show conflicting results regarding the serum levels of this hormone in patients with endometriosis and response to ART (3, 4). So considering the lack of sufficient studies and conflicting results of previous studies about the level of serum AMH, ovarian reserve and ART response in patients with endometriosis, we investigated the level of AMH serum and its association with response to ART in patients with endometriosis. This could help to determine the best therapeutic approach by measuring AMH as a routine test before any therapeutic intervention to increase chances of fertility in these patients. Materials and methods In this case-control study, patients were examined with idiopathic infertility or tubal factor infertility who were candidate for first IVF cycle and were referred to Shariati Hospital in 2015-2017. According to the laparoscopy treatment, before starting the cycle patients were divided into two groups; 32 patients as endometriosis and 32 patients without endometriosis as control group. Also in the endometriosis group, severity of disease was classified according to ARSM system. It should be noted that in both groups, those with the following characteristics were excluded from the study: 1. Age over 40 yr I Downloaded from journals.ssu.ac.ir at 11:23 +0330 on Friday December 3rd 2021