Arch Clin Biomed Res 2021; 5 (6): 1000-1003 DOI: 10.26502/acbr.50170218 Archives of Clinical and Biomedical Research Vol. 5 No. 6 – December 2021. [ISSN 2572-9292]. 1000 Short Communication Glucose-6-phosphate Dehydrogenase (G6PD) Deficiency and its Relation to Covid-19 Ayse Sahin Tutak 1* , Hakan Sezgin Sayiner 2 1 Department of Internal Medicine, Adıyaman University School of Medicine, Adıyaman, Turkey 2 Department of Infectious Disease, Adıyaman University School of Medicine, Adıyaman, Turkey *Corresponding author: Ayse Sahin Tutak, Department of Internal Medicine, Adıyaman University School of Medicine, Adıyaman, Turkey Received: 22 November 2021; Accepted: 14 December 2021; Published: 20 December 2021 Citation: Ayse Sahin Tutak, Hakan Sezgin Sayiner. Glucose-6-phosphate Dehydrogenase (G6PD) Deficiency and its Relation to Covid-19. Archives of Clinical and Biomedical Research 5 (2021): 1000-1003. Short Communication Glucose-6-phosphate dehydrogenase (G6PD) def- iciency is the most common enzymopathy world- wide. It is prevalent in approximately 400 million people in East and Southeast Asia and central Africa [1, 2]. G6PD is an enzyme with X-linked recessive inheritance. Its level of activity varies among individuals and due to various drugs and foods. The level of enzyme activity decreases with aging. Clinically, men develop conditions, while women are carriers. G6PD deficiency is classified by the level of enzyme activity, and patients may suffer from mild/moderate G6PD deficiency. In the most severe type, the level of enzyme activity is below 10% [3]. It catalyzes the first and rate-limiting reaction step in the hexose monophosphate (HMP) pathway G6PD and provides the conversion of NADP to NADPH (nicotinamide adenine dinucleotide phosphate). G6PD deficiency results in a lack of NADPH production. NADPH plays an important role in maintaining the integrity of the cell membrane in erythrocytes [4] and protects the erythrocytes against oxidative stress. Its deficiency may result in hemolysis of different severity and endothelial dysfunction in different tissues due to exposure to various factors. G6PD is also known to be essential in preventing opacification of the eye and for the development of cells of the lens. Studies on different age groups have found a strong correlation between G6PD deficiency in erythrocyte cells and cataract formation [5, 6]. One of the factors in the etiology of neonatal jaundice is G6PD deficiency [7]. G6PD deficiency has been found to vary from 1.5% to 35% in infants with jaundice [8].